FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557564204> ?p ?o ?g. }

• W2557564204 endingPage "260" @default.
• W2557564204 startingPage "249" @default.
• W2557564204 abstract "Coronary heart disease is still the leading cause of death in industrialized nations. Even though revascularization strategies such as coronary artery bypass graft surgery, percutaneous coronary intervention and enhanced drug therapy significantly improved the outcome, about 30 % of patients develop chronic heart failure. Ischemic heart disease and heart failure are characterized by an adverse remodeling of the heart, featuring cardiomyocyte hypertrophy, increased fibrosis and capillary rarefaction. Therefore, gene therapeutic approaches for the treatment of heart failure, such as the modulating contractile function or therapeutic neovascularization, seem to be promising. To achieve an efficient transduction of the gene therapeutic agent, the time point and the application route seem to be important for the therapeutic success. In contrast to the classical systemic application regional intra-coronary application offers the possibility of higher transduction efficacy in the target area accompanied by a reduced off-target contamination. Antegrade delivery however, may be impaired by coronary heart disease, such as stenosis or occlusion of a coronary artery. Coronary veins appear not to be affected and might therefore be the preferable application route for gene therapy. For an effective and safe retrograde application in gene therapy, selective catheterization of the coronary vein draining the target area is necessary. In addition, to avoid coronary vein injury, a pressure regulated infusion enhances safety. Therefore, a selective pressure regulation of retroinfusion (SSR) seems to be a favorable approach for gene therapy transduction in combination with reduced systemic contamination." @default.
• W2557564204 created "2016-12-08" @default.
• W2557564204 creator A5045094613 @default.
• W2557564204 creator A5056456336 @default.
• W2557564204 date "2016-12-02" @default.
• W2557564204 modified "2023-09-25" @default.
• W2557564204 title "Selective Pressure-Regulated Retroinfusion for Gene Therapy Application in Ischemic Heart Disease" @default.
• W2557564204 cites W158281719 @default.
• W2557564204 cites W1987690922 @default.
• W2557564204 cites W1988553534 @default.
• W2557564204 cites W1992290627 @default.
• W2557564204 cites W1998180965 @default.
• W2557564204 cites W2020468542 @default.
• W2557564204 cites W2054554278 @default.
• W2557564204 cites W2056443732 @default.
• W2557564204 cites W2056905507 @default.
• W2557564204 cites W2072186976 @default.
• W2557564204 cites W2074771766 @default.
• W2557564204 cites W2076152336 @default.
• W2557564204 cites W2078914940 @default.
• W2557564204 cites W2082884613 @default.
• W2557564204 cites W2085616957 @default.
• W2557564204 cites W2090544953 @default.
• W2557564204 cites W2101102924 @default.
• W2557564204 cites W2101385080 @default.
• W2557564204 cites W2110557028 @default.
• W2557564204 cites W2112359061 @default.
• W2557564204 cites W2117903449 @default.
• W2557564204 cites W2126617656 @default.
• W2557564204 cites W2139918394 @default.
• W2557564204 cites W2148009707 @default.
• W2557564204 cites W2148092448 @default.
• W2557564204 cites W2614781785 @default.
• W2557564204 cites W4211206238 @default.
• W2557564204 cites W73157313 @default.
• W2557564204 cites W787851930 @default.
• W2557564204 doi "https://doi.org/10.1007/978-1-4939-6588-5_18" @default.
• W2557564204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27910055" @default.
• W2557564204 hasPublicationYear "2016" @default.
• W2557564204 type Work @default.
• W2557564204 sameAs 2557564204 @default.
• W2557564204 citedByCount "4" @default.
• W2557564204 countsByYear W25575642042019 @default.
• W2557564204 countsByYear W25575642042020 @default.
• W2557564204 countsByYear W25575642042022 @default.
• W2557564204 crossrefType "book-chapter" @default.
• W2557564204 hasAuthorship W2557564204A5045094613 @default.
• W2557564204 hasAuthorship W2557564204A5056456336 @default.
• W2557564204 hasConcept C126322002 @default.
• W2557564204 hasConcept C164705383 @default.
• W2557564204 hasConcept C2776820930 @default.
• W2557564204 hasConcept C2778198053 @default.
• W2557564204 hasConcept C2778213512 @default.
• W2557564204 hasConcept C2778742706 @default.
• W2557564204 hasConcept C2779464278 @default.
• W2557564204 hasConcept C2780400711 @default.
• W2557564204 hasConcept C500558357 @default.
• W2557564204 hasConcept C71924100 @default.
• W2557564204 hasConceptScore W2557564204C126322002 @default.
• W2557564204 hasConceptScore W2557564204C164705383 @default.
• W2557564204 hasConceptScore W2557564204C2776820930 @default.
• W2557564204 hasConceptScore W2557564204C2778198053 @default.
• W2557564204 hasConceptScore W2557564204C2778213512 @default.
• W2557564204 hasConceptScore W2557564204C2778742706 @default.
• W2557564204 hasConceptScore W2557564204C2779464278 @default.
• W2557564204 hasConceptScore W2557564204C2780400711 @default.
• W2557564204 hasConceptScore W2557564204C500558357 @default.
• W2557564204 hasConceptScore W2557564204C71924100 @default.
• W2557564204 hasLocation W25575642041 @default.
• W2557564204 hasLocation W25575642042 @default.
• W2557564204 hasOpenAccess W2557564204 @default.
• W2557564204 hasPrimaryLocation W25575642041 @default.
• W2557564204 hasRelatedWork W2104888105 @default.
• W2557564204 hasRelatedWork W2125804349 @default.
• W2557564204 hasRelatedWork W2150793174 @default.
• W2557564204 hasRelatedWork W2334320217 @default.
• W2557564204 hasRelatedWork W2351880569 @default.
• W2557564204 hasRelatedWork W2399063111 @default.
• W2557564204 hasRelatedWork W2919932825 @default.
• W2557564204 hasRelatedWork W2981847246 @default.
• W2557564204 hasRelatedWork W3093656048 @default.
• W2557564204 hasRelatedWork W3141700921 @default.
• W2557564204 isParatext "false" @default.
• W2557564204 isRetracted "false" @default.
• W2557564204 magId "2557564204" @default.
• W2557564204 workType "book-chapter" @default.