Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557564418> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2557564418 abstract "Abstract ONC201 is a first-in-class small molecule inducer of the integrated stress response that is currently in phase II clinical trials in select advanced cancers with promising early clinical results. The efficacy of this novel agent has been demonstrated in numerous preclinical advance cancer models in multiple indications with an exceptional safety profile that has translated well to the clinic. To determine the preclinical sensitivity profile of ONC201 in cancer, we performed an in vitro efficacy screen across >1,000 human cancer cell lines that represent a diverse array of tumor types and genetic aberrations. Sensitivity profiling was assessed by cell viability assays using dose responses curves at concentrations up to 20uM and at 72 hours post-treatment. Ranking the sensitivity dataset by tumor type, non-Hodgkin's lymphomas and multiple myeloma were the most sensitive tumor type to ONC201. The mutation-agnostic efficacy that is most pronounced in lymphomas and multiple myeloma is in accordance with the recent findings that ONC201 induces the integrated stress response through a novel target to trigger is downstream late apoptotic effects. B-cell malignancies are particularly susceptible to induction of apoptosis via the integrated stress response, as they have relatively high basal activation of this pathway due to ER stress conferred by immunoglobulin production. Confirmatory studies revealed that multiple myeloma cell lines indeed possess pronounced sensitivity with nanomolar GI50s, unlike most other tumor types, that is particularly encouraging given the systemic concentrations observed in the first-in-man study. Together, these studies suggest specific advanced cancer indications, such as non-Hodgkin's lymphoma and multiple myeloma, as promising lead indications for this novel agent that are being evaluated in phase II clinical trials. Disclosures Allen: Oncoceutics, Inc: Employment, Equity Ownership. Tarapore:Oncoceutics, Inc: Employment, Equity Ownership." @default.
- W2557564418 created "2016-12-08" @default.
- W2557564418 creator A5008547275 @default.
- W2557564418 creator A5045679809 @default.
- W2557564418 creator A5060699951 @default.
- W2557564418 creator A5085472676 @default.
- W2557564418 date "2015-12-03" @default.
- W2557564418 modified "2023-09-28" @default.
- W2557564418 title "ONC201 Exhibits Mutation-Independent Efficacy with Superior Potency in Non-Hodgkin Lymphoma and Multiple Myeloma" @default.
- W2557564418 doi "https://doi.org/10.1182/blood.v126.23.3873.3873" @default.
- W2557564418 hasPublicationYear "2015" @default.
- W2557564418 type Work @default.
- W2557564418 sameAs 2557564418 @default.
- W2557564418 citedByCount "0" @default.
- W2557564418 crossrefType "journal-article" @default.
- W2557564418 hasAuthorship W2557564418A5008547275 @default.
- W2557564418 hasAuthorship W2557564418A5045679809 @default.
- W2557564418 hasAuthorship W2557564418A5060699951 @default.
- W2557564418 hasAuthorship W2557564418A5085472676 @default.
- W2557564418 hasConcept C104317684 @default.
- W2557564418 hasConcept C105580179 @default.
- W2557564418 hasConcept C121608353 @default.
- W2557564418 hasConcept C126322002 @default.
- W2557564418 hasConcept C143998085 @default.
- W2557564418 hasConcept C149364088 @default.
- W2557564418 hasConcept C203014093 @default.
- W2557564418 hasConcept C2776364478 @default.
- W2557564418 hasConcept C2777938653 @default.
- W2557564418 hasConcept C2778461978 @default.
- W2557564418 hasConcept C2779338263 @default.
- W2557564418 hasConcept C2779638656 @default.
- W2557564418 hasConcept C2779675984 @default.
- W2557564418 hasConcept C502942594 @default.
- W2557564418 hasConcept C54355233 @default.
- W2557564418 hasConcept C71924100 @default.
- W2557564418 hasConcept C86803240 @default.
- W2557564418 hasConceptScore W2557564418C104317684 @default.
- W2557564418 hasConceptScore W2557564418C105580179 @default.
- W2557564418 hasConceptScore W2557564418C121608353 @default.
- W2557564418 hasConceptScore W2557564418C126322002 @default.
- W2557564418 hasConceptScore W2557564418C143998085 @default.
- W2557564418 hasConceptScore W2557564418C149364088 @default.
- W2557564418 hasConceptScore W2557564418C203014093 @default.
- W2557564418 hasConceptScore W2557564418C2776364478 @default.
- W2557564418 hasConceptScore W2557564418C2777938653 @default.
- W2557564418 hasConceptScore W2557564418C2778461978 @default.
- W2557564418 hasConceptScore W2557564418C2779338263 @default.
- W2557564418 hasConceptScore W2557564418C2779638656 @default.
- W2557564418 hasConceptScore W2557564418C2779675984 @default.
- W2557564418 hasConceptScore W2557564418C502942594 @default.
- W2557564418 hasConceptScore W2557564418C54355233 @default.
- W2557564418 hasConceptScore W2557564418C71924100 @default.
- W2557564418 hasConceptScore W2557564418C86803240 @default.
- W2557564418 hasLocation W25575644181 @default.
- W2557564418 hasOpenAccess W2557564418 @default.
- W2557564418 hasPrimaryLocation W25575644181 @default.
- W2557564418 hasRelatedWork W1252738853 @default.
- W2557564418 hasRelatedWork W1578676949 @default.
- W2557564418 hasRelatedWork W1661248273 @default.
- W2557564418 hasRelatedWork W1964255969 @default.
- W2557564418 hasRelatedWork W1972994428 @default.
- W2557564418 hasRelatedWork W2013220648 @default.
- W2557564418 hasRelatedWork W2074068184 @default.
- W2557564418 hasRelatedWork W2141983591 @default.
- W2557564418 hasRelatedWork W2339624602 @default.
- W2557564418 hasRelatedWork W2410502612 @default.
- W2557564418 hasRelatedWork W2481651821 @default.
- W2557564418 hasRelatedWork W2484042796 @default.
- W2557564418 hasRelatedWork W2498045732 @default.
- W2557564418 hasRelatedWork W2510922660 @default.
- W2557564418 hasRelatedWork W2521762686 @default.
- W2557564418 hasRelatedWork W2571542360 @default.
- W2557564418 hasRelatedWork W2611202690 @default.
- W2557564418 hasRelatedWork W2979321854 @default.
- W2557564418 hasRelatedWork W2979693957 @default.
- W2557564418 hasRelatedWork W7783961 @default.
- W2557564418 isParatext "false" @default.
- W2557564418 isRetracted "false" @default.
- W2557564418 magId "2557564418" @default.
- W2557564418 workType "article" @default.