FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557592567> ?p ?o ?g. }

• W2557592567 abstract "It is known that the autophagy-related protein 1 (ATG1) plays critical roles in the regulation of autophagy in mammals and yeast, whereas the function of ATG1 in lepidopteran insects is not well elucidated. Here Spodoptera litura ATG1 (SlATG1) and its interactions with other ATG proteins were characterized. Alternative splicing of SlAtg1 produced at least four transcript variants. Over-expression and RNA interference knockdown of SlAtg1 demonstrated that SlATG1 enhanced autophagy. SlATG1A-Green fluorescent protein (GFP) tagged localized in the cytoplasm and formed some punctuate dots, which were colocalized with red fluorescent protein mCherry tagged Spodoptera exigua ATG5 (SeATG5). SlATG1A-GFP over-expression reduced the nuclear abundance of mCherry-SeATG5 but increased its cytoplasmic abundance. Pull-down, co-immunoprecipitation and bimolecular fluorescence complementation assays showed that SlATG1A bound to SeATG5 through the N-terminus of SlATG1A. The over-expression of FLAG epitope tagged SlATG1A significantly increased the accumulation of the cleaved GFP from GFP-SeATG5, suggesting the enhanced degradation of GFP-SeATG5. In addition, we confirmed that the interactions of SlATG1 with other autophagy-related proteins were conserved. These results provide the first evidence that ATG1 interacts with ATG5 and enhances its degradation in lepidopteran insect cells, which may have important physiological functions." @default.
• W2557592567 created "2016-12-08" @default.
• W2557592567 creator A5000437598 @default.
• W2557592567 creator A5003094481 @default.
• W2557592567 creator A5006149260 @default.
• W2557592567 creator A5015105956 @default.
• W2557592567 creator A5015861023 @default.
• W2557592567 creator A5016514653 @default.
• W2557592567 creator A5022636859 @default.
• W2557592567 creator A5036444950 @default.
• W2557592567 creator A5042612194 @default.
• W2557592567 creator A5075828120 @default.
• W2557592567 creator A5084614615 @default.
• W2557592567 creator A5090602006 @default.
• W2557592567 date "2016-11-30" @default.
• W2557592567 modified "2023-09-24" @default.
• W2557592567 title "Spodoptera lituraautophagy-related protein 1 interacts with autophagy-related protein 5 and enhances its degradation" @default.
• W2557592567 cites W1539208238 @default.
• W2557592567 cites W1593850395 @default.
• W2557592567 cites W1754519657 @default.
• W2557592567 cites W1964257510 @default.
• W2557592567 cites W1971121986 @default.
• W2557592567 cites W1974115318 @default.
• W2557592567 cites W1974504670 @default.
• W2557592567 cites W1979788838 @default.
• W2557592567 cites W1985600706 @default.
• W2557592567 cites W1992659717 @default.
• W2557592567 cites W1993231978 @default.
• W2557592567 cites W1999211990 @default.
• W2557592567 cites W2001160077 @default.
• W2557592567 cites W2013834631 @default.
• W2557592567 cites W2015541033 @default.
• W2557592567 cites W2029955148 @default.
• W2557592567 cites W2031693373 @default.
• W2557592567 cites W2039838459 @default.
• W2557592567 cites W2039906257 @default.
• W2557592567 cites W2043409309 @default.
• W2557592567 cites W2054536403 @default.
• W2557592567 cites W2063650770 @default.
• W2557592567 cites W2065592028 @default.
• W2557592567 cites W2068381144 @default.
• W2557592567 cites W2073738565 @default.
• W2557592567 cites W2076570319 @default.
• W2557592567 cites W2079282879 @default.
• W2557592567 cites W2082865308 @default.
• W2557592567 cites W2085771011 @default.
• W2557592567 cites W2086623584 @default.
• W2557592567 cites W2087209616 @default.
• W2557592567 cites W2096065711 @default.
• W2557592567 cites W2108086395 @default.
• W2557592567 cites W2129047394 @default.
• W2557592567 cites W2146122852 @default.
• W2557592567 cites W2161803468 @default.
• W2557592567 cites W2164998112 @default.
• W2557592567 cites W2167430243 @default.
• W2557592567 cites W2170973789 @default.
• W2557592567 cites W2205539307 @default.
• W2557592567 cites W2229841637 @default.
• W2557592567 cites W2333128207 @default.
• W2557592567 cites W2403731672 @default.
• W2557592567 cites W2507700403 @default.
• W2557592567 doi "https://doi.org/10.1111/imb.12284" @default.
• W2557592567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27902874" @default.
• W2557592567 hasPublicationYear "2016" @default.
• W2557592567 type Work @default.
• W2557592567 sameAs 2557592567 @default.
• W2557592567 citedByCount "3" @default.
• W2557592567 countsByYear W25575925672020 @default.
• W2557592567 countsByYear W25575925672021 @default.
• W2557592567 countsByYear W25575925672022 @default.
• W2557592567 crossrefType "journal-article" @default.
• W2557592567 hasAuthorship W2557592567A5000437598 @default.
• W2557592567 hasAuthorship W2557592567A5003094481 @default.
• W2557592567 hasAuthorship W2557592567A5006149260 @default.
• W2557592567 hasAuthorship W2557592567A5015105956 @default.
• W2557592567 hasAuthorship W2557592567A5015861023 @default.
• W2557592567 hasAuthorship W2557592567A5016514653 @default.
• W2557592567 hasAuthorship W2557592567A5022636859 @default.
• W2557592567 hasAuthorship W2557592567A5036444950 @default.
• W2557592567 hasAuthorship W2557592567A5042612194 @default.
• W2557592567 hasAuthorship W2557592567A5075828120 @default.
• W2557592567 hasAuthorship W2557592567A5084614615 @default.
• W2557592567 hasAuthorship W2557592567A5090602006 @default.
• W2557592567 hasConcept C104317684 @default.
• W2557592567 hasConcept C123243835 @default.
• W2557592567 hasConcept C142613039 @default.
• W2557592567 hasConcept C153911025 @default.
• W2557592567 hasConcept C166703698 @default.
• W2557592567 hasConcept C173396325 @default.
• W2557592567 hasConcept C173758957 @default.
• W2557592567 hasConcept C190283241 @default.
• W2557592567 hasConcept C203522944 @default.
• W2557592567 hasConcept C2776273252 @default.
• W2557592567 hasConcept C2777773057 @default.
• W2557592567 hasConcept C2779222958 @default.
• W2557592567 hasConcept C2779260011 @default.
• W2557592567 hasConcept C2781000418 @default.
• W2557592567 hasConcept C2992195973 @default.
• W2557592567 hasConcept C40767141 @default.
• W2557592567 hasConcept C55493867 @default.

• next