FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557671700> ?p ?o ?g. }

• W2557671700 abstract "Acute hyperglycemia causes endothelial dysfunction in diabetic patients, abolishes ischemic pre- and postconditioning, and is an independent predictor of adverse outcome after myocardial infarction in nondiabetic patients. Its effects on endothelial-dependent vasodilation are controversial in healthy subjects. The authors studied the effect of moderate short-term local hyperglycemia on forearm endothelium-dependent vasodilation in healthy volunteers.Randomized, crossover, blinded, 2-visit, pilot design.Veterans Affairs Medical Center.Five male and 3 female healthy adult volunteers (23±4 years; height 171±13 cm; weight 66±9 kg; [mean±standard error of the mean]).At each visit, volunteers received an infusion through a brachial artery catheter of either 0.9% saline or dextrose in the experimental, non-dominant arm, to establish mild forearm hyperglycemia. Hemodynamics and forearm blood flow (FBF; plethysmography) were measured at baseline, during brachial artery infusions of acetylcholine in consecutive increments (5, 10, and 15 μg/min), before ischemia (20 min, blood pressure cuff at 200 mmHg), and after 15 minutes of reperfusion. Blood glucose and insulin concentrations were determined from venous samples. The effect of duration of intra-arterial dextrose on FBF was examined.Dextrose increased steady-state blood glucose concentration in the experimental but not the control arm (dominant arm). Dextrose increased FBF compared with saline (4.5±0.5 v 2.6±0.4 mL/min/100 g of tissue, respectively). Acetylcholine caused similar increases in FBF in the absence and presence of dextrose (+239±90% v+203±75%, respectively, during 15 μg/min). The duration of dextrose did not affect this acetylcholine-induced vasodilation. Acetylcholine-stimulated increases in FBF were attenuated in dextrose-treated versus saline after reperfusion (+180±18% v+257±53%, respectively, during 10 μg/min). Interventions in the experimental arm did not affect FBF in the control arm.These results indicated that moderate, short-term, local hyperglycemia induced by intra-arterial administration of dextrose attenuated forearm endothelial-dependent vasodilation after ischemia-reperfusion injury in healthy volunteers." @default.
• W2557671700 created "2016-12-08" @default.
• W2557671700 creator A5015027315 @default.
• W2557671700 creator A5016669806 @default.
• W2557671700 creator A5019634669 @default.
• W2557671700 creator A5028909676 @default.
• W2557671700 creator A5047276993 @default.
• W2557671700 creator A5064918807 @default.
• W2557671700 creator A5068638830 @default.
• W2557671700 date "2017-10-01" @default.
• W2557671700 modified "2023-10-14" @default.
• W2557671700 title "Moderate, Short-Term, Local Hyperglycemia Attenuates Forearm Endothelium-Dependent Vasodilation After Transient Ischemia-Reperfusion in Human Volunteers" @default.
• W2557671700 cites W1605590279 @default.
• W2557671700 cites W1972352298 @default.
• W2557671700 cites W1977218734 @default.
• W2557671700 cites W1985399016 @default.
• W2557671700 cites W1990800912 @default.
• W2557671700 cites W2000625731 @default.
• W2557671700 cites W2001466438 @default.
• W2557671700 cites W2001584733 @default.
• W2557671700 cites W2004760771 @default.
• W2557671700 cites W2025868889 @default.
• W2557671700 cites W2028695980 @default.
• W2557671700 cites W2031414255 @default.
• W2557671700 cites W2044833426 @default.
• W2557671700 cites W2074858865 @default.
• W2557671700 cites W2080221106 @default.
• W2557671700 cites W2089736652 @default.
• W2557671700 cites W2093441969 @default.
• W2557671700 cites W2103867046 @default.
• W2557671700 cites W2106776242 @default.
• W2557671700 cites W2107545755 @default.
• W2557671700 cites W2117628685 @default.
• W2557671700 cites W2122648697 @default.
• W2557671700 cites W2123560318 @default.
• W2557671700 cites W2136086651 @default.
• W2557671700 cites W2145675604 @default.
• W2557671700 cites W2149522258 @default.
• W2557671700 cites W2159863383 @default.
• W2557671700 cites W2161474086 @default.
• W2557671700 cites W2163376944 @default.
• W2557671700 cites W2228705256 @default.
• W2557671700 cites W2275514968 @default.
• W2557671700 cites W2281735941 @default.
• W2557671700 cites W2345007910 @default.
• W2557671700 cites W2769264260 @default.
• W2557671700 doi "https://doi.org/10.1053/j.jvca.2016.11.040" @default.
• W2557671700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28284926" @default.
• W2557671700 hasPublicationYear "2017" @default.
• W2557671700 type Work @default.
• W2557671700 sameAs 2557671700 @default.
• W2557671700 citedByCount "2" @default.
• W2557671700 countsByYear W25576717002019 @default.
• W2557671700 countsByYear W25576717002021 @default.
• W2557671700 crossrefType "journal-article" @default.
• W2557671700 hasAuthorship W2557671700A5015027315 @default.
• W2557671700 hasAuthorship W2557671700A5016669806 @default.
• W2557671700 hasAuthorship W2557671700A5019634669 @default.
• W2557671700 hasAuthorship W2557671700A5028909676 @default.
• W2557671700 hasAuthorship W2557671700A5047276993 @default.
• W2557671700 hasAuthorship W2557671700A5064918807 @default.
• W2557671700 hasAuthorship W2557671700A5068638830 @default.
• W2557671700 hasConcept C120770815 @default.
• W2557671700 hasConcept C126322002 @default.
• W2557671700 hasConcept C141071460 @default.
• W2557671700 hasConcept C142724271 @default.
• W2557671700 hasConcept C164705383 @default.
• W2557671700 hasConcept C178853913 @default.
• W2557671700 hasConcept C204787440 @default.
• W2557671700 hasConcept C27081682 @default.
• W2557671700 hasConcept C2777397205 @default.
• W2557671700 hasConcept C2777604165 @default.
• W2557671700 hasConcept C2780214079 @default.
• W2557671700 hasConcept C42219234 @default.
• W2557671700 hasConcept C541997718 @default.
• W2557671700 hasConcept C71924100 @default.
• W2557671700 hasConcept C73362275 @default.
• W2557671700 hasConcept C84393581 @default.
• W2557671700 hasConcept C87813604 @default.
• W2557671700 hasConceptScore W2557671700C120770815 @default.
• W2557671700 hasConceptScore W2557671700C126322002 @default.
• W2557671700 hasConceptScore W2557671700C141071460 @default.
• W2557671700 hasConceptScore W2557671700C142724271 @default.
• W2557671700 hasConceptScore W2557671700C164705383 @default.
• W2557671700 hasConceptScore W2557671700C178853913 @default.
• W2557671700 hasConceptScore W2557671700C204787440 @default.
• W2557671700 hasConceptScore W2557671700C27081682 @default.
• W2557671700 hasConceptScore W2557671700C2777397205 @default.
• W2557671700 hasConceptScore W2557671700C2777604165 @default.
• W2557671700 hasConceptScore W2557671700C2780214079 @default.
• W2557671700 hasConceptScore W2557671700C42219234 @default.
• W2557671700 hasConceptScore W2557671700C541997718 @default.
• W2557671700 hasConceptScore W2557671700C71924100 @default.
• W2557671700 hasConceptScore W2557671700C73362275 @default.
• W2557671700 hasConceptScore W2557671700C84393581 @default.
• W2557671700 hasConceptScore W2557671700C87813604 @default.
• W2557671700 hasLocation W25576717001 @default.
• W2557671700 hasLocation W25576717002 @default.
• W2557671700 hasOpenAccess W2557671700 @default.
• W2557671700 hasPrimaryLocation W25576717001 @default.

• next