FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557681536> ?p ?o ?g. }

• W2557681536 abstract "Abstract Thyroid hormone has been recently shown to induce tumor growth and angiogenesis. These angiogenesis modulating activities are initiated at endothelial cell plasma membrane receptor via the integrin αVβ3, at or near the Arg-Gly-Asp (RGD) recognition site on the integrin. In the present study, we have investigated the effect of tetraiodothyroacetic acid (tetrac), a deaminated thyroid hormone analog that inhibits thyroid hormone-binding to the cell surface integrin, on angiogenesis and cancer cell resistance to doxorubicin both in vitro and in vivo. Two angiogenesis models were studied in which vascular endothelial growth factor, VEGF165 or basic fibroblast growth factor, FGF2 (1–2 μg/ml) or thyroid hormone, thyroxin (L-T4 or T3) were used either to induce tube formation in the human dermal micro-vascular endothelial cells (HDMEC), or to stimulate new blood vessel branch formation in the chick chorioallantoic membrane (CAM) models. In both models, Tetrac (0.1–10 μM) inhibited the pro-angiogenesis activity of VEGF, FGF2, L-T4 or T3 by more than 50% at 1.0 uM RT-PCR revealed that tetrac (1–3 μM) decreased abundance of angiopoietin-2 mRNA but did not affect the mRNA levels of angiopoietin-1, in VEGF-exposed endothelial cells, suggesting that specific angiogenic pathways are targeted by this compound. Additionally, microarray was used to examine changes in expression of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) following VEGF treatment with and without tetrac. HDMEC cells treated with VEGF exhibited 3–5-fold increase in MMP-15 and MMP-19 expression and tetrac (3μM), inhibited expression of MMP-15 and MMP-19 by 3–9-fold, respectively. Expression of TIMP-3 was increased 5.4-fold following VEGF and tetrac treatment when compared to treatment with VEGF alone. This finding suggests that part of the mechanism by which tetrac inhibits VEGF-stimulated angiogenesis involves inhibition of certain MMPs and increase in TIMP expression. Investigation of the anti-proliferative function of tetrac was carried out using the αVβ3 expressing breast cancer cells MC7 and their drug resistant counterparts. Interestingly, proliferation of both cell lines was inhibited similarly by tetrac suggesting that this analog may circumvent drug resistance. In fact, tetrac was able to reverse resistance to doxorubicin in vitro and to suppress growth of doxorubicin resistant tumors in nude mice. Inhibition of the drug transporter p-glycoprotein was found to play a key role in mediating the action of tetrac. Taken together, findings presented in this study provide evidence that the anticancer function of tetrac can be attributed to its anti-angiogenic and drug resistance reversal activities." @default.
• W2557681536 created "2016-12-08" @default.
• W2557681536 creator A5032045966 @default.
• W2557681536 creator A5032881983 @default.
• W2557681536 creator A5041508551 @default.
• W2557681536 creator A5053367715 @default.
• W2557681536 creator A5064680897 @default.
• W2557681536 date "2007-11-16" @default.
• W2557681536 modified "2023-09-27" @default.
• W2557681536 title "Suppression of Angiogenesis and Resistance to Doxorubicin by the Thyroid Hormone Tetraiodothyroacetic Acid." @default.
• W2557681536 doi "https://doi.org/10.1182/blood.v110.11.4209.4209" @default.
• W2557681536 hasPublicationYear "2007" @default.
• W2557681536 type Work @default.
• W2557681536 sameAs 2557681536 @default.
• W2557681536 citedByCount "0" @default.
• W2557681536 crossrefType "journal-article" @default.
• W2557681536 hasAuthorship W2557681536A5032045966 @default.
• W2557681536 hasAuthorship W2557681536A5032881983 @default.
• W2557681536 hasAuthorship W2557681536A5041508551 @default.
• W2557681536 hasAuthorship W2557681536A5053367715 @default.
• W2557681536 hasAuthorship W2557681536A5064680897 @default.
• W2557681536 hasConcept C109115496 @default.
• W2557681536 hasConcept C109523444 @default.
• W2557681536 hasConcept C123012128 @default.
• W2557681536 hasConcept C126322002 @default.
• W2557681536 hasConcept C134018914 @default.
• W2557681536 hasConcept C146285616 @default.
• W2557681536 hasConcept C167734588 @default.
• W2557681536 hasConcept C170493617 @default.
• W2557681536 hasConcept C185592680 @default.
• W2557681536 hasConcept C195687474 @default.
• W2557681536 hasConcept C202751555 @default.
• W2557681536 hasConcept C2775960820 @default.
• W2557681536 hasConcept C2777025900 @default.
• W2557681536 hasConcept C2777587049 @default.
• W2557681536 hasConcept C2780394083 @default.
• W2557681536 hasConcept C502942594 @default.
• W2557681536 hasConcept C526584372 @default.
• W2557681536 hasConcept C55493867 @default.
• W2557681536 hasConcept C71924100 @default.
• W2557681536 hasConcept C86803240 @default.
• W2557681536 hasConceptScore W2557681536C109115496 @default.
• W2557681536 hasConceptScore W2557681536C109523444 @default.
• W2557681536 hasConceptScore W2557681536C123012128 @default.
• W2557681536 hasConceptScore W2557681536C126322002 @default.
• W2557681536 hasConceptScore W2557681536C134018914 @default.
• W2557681536 hasConceptScore W2557681536C146285616 @default.
• W2557681536 hasConceptScore W2557681536C167734588 @default.
• W2557681536 hasConceptScore W2557681536C170493617 @default.
• W2557681536 hasConceptScore W2557681536C185592680 @default.
• W2557681536 hasConceptScore W2557681536C195687474 @default.
• W2557681536 hasConceptScore W2557681536C202751555 @default.
• W2557681536 hasConceptScore W2557681536C2775960820 @default.
• W2557681536 hasConceptScore W2557681536C2777025900 @default.
• W2557681536 hasConceptScore W2557681536C2777587049 @default.
• W2557681536 hasConceptScore W2557681536C2780394083 @default.
• W2557681536 hasConceptScore W2557681536C502942594 @default.
• W2557681536 hasConceptScore W2557681536C526584372 @default.
• W2557681536 hasConceptScore W2557681536C55493867 @default.
• W2557681536 hasConceptScore W2557681536C71924100 @default.
• W2557681536 hasConceptScore W2557681536C86803240 @default.
• W2557681536 hasLocation W25576815361 @default.
• W2557681536 hasOpenAccess W2557681536 @default.
• W2557681536 hasPrimaryLocation W25576815361 @default.
• W2557681536 hasRelatedWork W1525205194 @default.
• W2557681536 hasRelatedWork W1537089853 @default.
• W2557681536 hasRelatedWork W2039317622 @default.
• W2557681536 hasRelatedWork W2062627489 @default.
• W2557681536 hasRelatedWork W2084696027 @default.
• W2557681536 hasRelatedWork W2084768201 @default.
• W2557681536 hasRelatedWork W2095020812 @default.
• W2557681536 hasRelatedWork W2168981489 @default.
• W2557681536 hasRelatedWork W3174665696 @default.
• W2557681536 hasRelatedWork W71487439 @default.
• W2557681536 isParatext "false" @default.
• W2557681536 isRetracted "false" @default.
• W2557681536 magId "2557681536" @default.
• W2557681536 workType "article" @default.