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• W2557806072 abstract "MicroRNAs ( miRNAs )‐based therapy has recently emerged as a promising strategy in the treatments of neurodegenerative diseases. Thus, in this review, the most recent and important challenges and advances on the development of miRNA therapeutics for brain targeting are discussed. In particular, this review highlights current knowledge and progress in the field of manufacturing, recovery, isolation, purification, and analysis of these therapeutic oligonucleotides. Finally, the available miRNA delivery systems are reviewed and an analysis is presented in what concerns to the current challenges that have to be addressed to ensure their specificity and efficacy. Overall, it is intended to provide a perspective on the future of miRNA ‐based therapeutics, focusing the biotechnological approach to obtain miRNAs . WIREs RNA 2017, 8:e1409. doi: 10.1002/wrna.1409 This article is categorized under: RNA Processing > Processing of Small RNAs Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA in Disease and Development > RNA in Disease" @default.
• W2557806072 created "2016-12-08" @default.
• W2557806072 creator A5002377476 @default.
• W2557806072 creator A5024364625 @default.
• W2557806072 creator A5050360870 @default.
• W2557806072 creator A5051479989 @default.
• W2557806072 date "2016-11-24" @default.
• W2557806072 modified "2023-10-16" @default.
• W2557806072 title "Current progress on <scp>microRNAs</scp> ‐based therapeutics in neurodegenerative diseases" @default.
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