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- W2557874190 abstract "Current treatment methods for melanoma have some limitations such as less target-specific action, severe side effects and resistance to drugs. Significant progress has been made in exploring novel drug delivery systems based on suitable biochemical mechanisms using nanoparticles ranging from 10 to 400 nm for drug delivery and imaging, utilizing their enhanced penetration and retention properties. Poly-lactide-co-glycolide (PLGA), a copolymer of poly-lactic acid and poly-glycolic acid, provides an ideally suited performance-based design for better penetration into skin cells, thereby having a greater potential for the treatment of melanoma. Moreover, encapsulation protects the drug from deactivation by biological reactions and interactions with biomolecules, ensuring successful delivery and bioavailability for effective treatment. Controlled and sustained delivery of drugs across the skin barrier that otherwise prohibits entry of larger molecules can be successfully made with adequately stable biocompatible nanocarriers such as PLGA for taking drugs through the small cutaneous pores permitting targeted deposition and prolonged drug action. PLGA is now being extensively used in photodynamic therapy and targeted therapy through modulation of signal proteins and drug-DNA interactions. Recent advances made on these nanomedicines and their advantages in the treatment of skin melanoma are highlighted and discussed in this review." @default.
- W2557874190 created "2016-12-08" @default.
- W2557874190 creator A5022164679 @default.
- W2557874190 creator A5062727355 @default.
- W2557874190 date "2016-01-01" @default.
- W2557874190 modified "2023-10-17" @default.
- W2557874190 title "PLGA-loaded nanomedicines in melanoma treatment: Future prospect for efficient drug delivery" @default.
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- W2557874190 doi "https://doi.org/10.4103/0971-5916.195024" @default.
- W2557874190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5206868" @default.
- W2557874190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27934796" @default.
- W2557874190 hasPublicationYear "2016" @default.
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