FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557885712> ?p ?o ?g. }

• W2557885712 endingPage "4748" @default.
• W2557885712 startingPage "4742" @default.
• W2557885712 abstract "BACKGROUND:S2101 is one of the most potent LSD1 inhibitors, which can inhibit ovarian cancer cells viability. This study aimed to detect the mechanism behind the anticancer properties of S2101 in SKOV3 ovarian cells. MATERIAL AND METHODS:Cell viability was tested by Cell Counting Kit-8 (CCK-8) assay. Cellular apoptosis and autophagy were evaluated by flow cytometric analysis using Annexin-V/PI staining methods and Green fluorescent protein (GFP)-fused-LC3 (GFP-LC3), respectively. Western blotting was performed for analyzing the Bax, Bcl-2, mTOR, p- mTOR, p62, LC3-I, LC3-II, AKT, and p-AKT protein expression. RESULTS:Our results show that the proportion of early apoptotic and late apoptotic cells increased significantly for cells treated with S2101 at a concentration of 100 μM for 48 h. Treatment of S2101 in SKOV3 cells resulted in upregulation of Bax and downregulation of Bcl-2 in a time-dependent manner, indicating that S2101 can induce apoptosis in SKOV3. There was a downward trend in the expression of p62 when the SKOV3cells were treated with 100 µm S2101 for 12 h, 24 h and 48 h. The conversion of LC3-I to LC3-II was increased significantly at 24 h and 48 h. Autophagy was induced by S2101 in SKOV3 cells, evidenced by an increase in punctuate localization of GFP-LC3 and a change in expression of autophagy-related proteins. CONCLUSIONS:S2101 treatment decreased the levels of phosphorylated AKT and mTOR. S2101 inhibits SKOV3 cells viability and induces apoptosis and autophagy. The AKT/mTOR signaling pathway was found to be affected by S2101." @default.
• W2557885712 created "2016-12-08" @default.
• W2557885712 creator A5010729427 @default.
• W2557885712 creator A5011297387 @default.
• W2557885712 creator A5014264355 @default.
• W2557885712 creator A5085900440 @default.
• W2557885712 date "2016-12-03" @default.
• W2557885712 modified "2023-10-16" @default.
• W2557885712 title "Lysine-Specific Demethylase 1 (LSD1) Inhibitor S2101 Induces Autophagy via the AKT/mTOR Pathway in SKOV3 Ovarian Cancer Cells" @default.
• W2557885712 cites W1980673831 @default.
• W2557885712 cites W2002196794 @default.
• W2557885712 cites W2002636911 @default.
• W2557885712 cites W2003891642 @default.
• W2557885712 cites W2006942464 @default.
• W2557885712 cites W2007632818 @default.
• W2557885712 cites W2009125052 @default.
• W2557885712 cites W2022884475 @default.
• W2557885712 cites W2030466057 @default.
• W2557885712 cites W2034132952 @default.
• W2557885712 cites W2034488296 @default.
• W2557885712 cites W2042861906 @default.
• W2557885712 cites W2049528479 @default.
• W2557885712 cites W2054621094 @default.
• W2557885712 cites W2075796686 @default.
• W2557885712 cites W2086308175 @default.
• W2557885712 cites W2090333443 @default.
• W2557885712 cites W2093555475 @default.
• W2557885712 cites W2101054534 @default.
• W2557885712 cites W2119817124 @default.
• W2557885712 cites W2131752445 @default.
• W2557885712 cites W2137678309 @default.
• W2557885712 cites W2142942558 @default.
• W2557885712 cites W2143112776 @default.
• W2557885712 cites W2148748299 @default.
• W2557885712 cites W2156563694 @default.
• W2557885712 cites W2157320227 @default.
• W2557885712 cites W2160612217 @default.
• W2557885712 cites W2164778558 @default.
• W2557885712 cites W2170552969 @default.
• W2557885712 cites W2287750079 @default.
• W2557885712 cites W915005624 @default.
• W2557885712 doi "https://doi.org/10.12659/msm.898825" @default.
• W2557885712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5142589" @default.
• W2557885712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27914215" @default.
• W2557885712 hasPublicationYear "2016" @default.
• W2557885712 type Work @default.
• W2557885712 sameAs 2557885712 @default.
• W2557885712 citedByCount "29" @default.
• W2557885712 countsByYear W25578857122017 @default.
• W2557885712 countsByYear W25578857122018 @default.
• W2557885712 countsByYear W25578857122019 @default.
• W2557885712 countsByYear W25578857122020 @default.
• W2557885712 countsByYear W25578857122021 @default.
• W2557885712 countsByYear W25578857122022 @default.
• W2557885712 crossrefType "journal-article" @default.
• W2557885712 hasAuthorship W2557885712A5010729427 @default.
• W2557885712 hasAuthorship W2557885712A5011297387 @default.
• W2557885712 hasAuthorship W2557885712A5014264355 @default.
• W2557885712 hasAuthorship W2557885712A5085900440 @default.
• W2557885712 hasBestOaLocation W25578857122 @default.
• W2557885712 hasConcept C104317684 @default.
• W2557885712 hasConcept C127561419 @default.
• W2557885712 hasConcept C153911025 @default.
• W2557885712 hasConcept C185592680 @default.
• W2557885712 hasConcept C190283241 @default.
• W2557885712 hasConcept C203522944 @default.
• W2557885712 hasConcept C43060935 @default.
• W2557885712 hasConcept C502942594 @default.
• W2557885712 hasConcept C53227056 @default.
• W2557885712 hasConcept C553184892 @default.
• W2557885712 hasConcept C55493867 @default.
• W2557885712 hasConcept C62112901 @default.
• W2557885712 hasConcept C75217442 @default.
• W2557885712 hasConcept C86554907 @default.
• W2557885712 hasConcept C86803240 @default.
• W2557885712 hasConcept C88634738 @default.
• W2557885712 hasConcept C95444343 @default.
• W2557885712 hasConceptScore W2557885712C104317684 @default.
• W2557885712 hasConceptScore W2557885712C127561419 @default.
• W2557885712 hasConceptScore W2557885712C153911025 @default.
• W2557885712 hasConceptScore W2557885712C185592680 @default.
• W2557885712 hasConceptScore W2557885712C190283241 @default.
• W2557885712 hasConceptScore W2557885712C203522944 @default.
• W2557885712 hasConceptScore W2557885712C43060935 @default.
• W2557885712 hasConceptScore W2557885712C502942594 @default.
• W2557885712 hasConceptScore W2557885712C53227056 @default.
• W2557885712 hasConceptScore W2557885712C553184892 @default.
• W2557885712 hasConceptScore W2557885712C55493867 @default.
• W2557885712 hasConceptScore W2557885712C62112901 @default.
• W2557885712 hasConceptScore W2557885712C75217442 @default.
• W2557885712 hasConceptScore W2557885712C86554907 @default.
• W2557885712 hasConceptScore W2557885712C86803240 @default.
• W2557885712 hasConceptScore W2557885712C88634738 @default.
• W2557885712 hasConceptScore W2557885712C95444343 @default.
• W2557885712 hasLocation W25578857121 @default.
• W2557885712 hasLocation W25578857122 @default.
• W2557885712 hasLocation W25578857123 @default.
• W2557885712 hasLocation W25578857124 @default.

• next