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• W2557948476 abstract "Abstract The root-knot nematode Meloidogyne incognita causes severe damage to continuously cropping vegetables. The control of this nematode relies heavily on organophosphate nematicides in China. Here, we described resistance to the organophosphate nematicide fosthiazate in a greenhouse-collected resistant population (RP) and a laboratory susceptible population (SP) of M. incognita . Fosthiazate was 2.74-fold less toxic to nematodes from RP than that from SP. Quantitative real-time PCR revealed that the acetylcholinesterase2 ( ace 2) transcription level in the RP was significantly higher than that in the SP. Eighteen nonsynonymous amino acid differences in ace2 were observed between the cDNA fragments of the RP and SP. The acetylcholinesterase (AChE) protein activity in the RP was significantly reduced compared with that in the SP. After knocking down the ace 2 gene, the ace 2 transcription level was significantly decreased, but no negative impact on the infection of juveniles was observed. The 50% lethal concentration of the RNAi RP population decreased 40%, but the inhibition rate of fosthiazate against AChE activity was significantly increased in RP population. Thus, the increased fosthiazate insensitivity in the M. incognita resistant population was strongly associated with mutations in ace 2. These results provide valuable insights into the resistance mechanism of root-knot nematode to organophosphate nematicides." @default.
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• W2557948476 date "2016-11-29" @default.
• W2557948476 modified "2023-10-02" @default.
• W2557948476 title "Mutations in Acetylcholinesterase2 (ace2) increase the insensitivity of acetylcholinesterase to fosthiazate in the root-knot nematode Meloidogyne incognita" @default.
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• W2557948476 doi "https://doi.org/10.1038/srep38102" @default.
• W2557948476 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5126670" @default.
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