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• W2557950677 abstract "Peripheral T-cell lymphomas (PTCLs) are rare, heterogeneous tumors with poor response to standard therapy and few targeted treatments available. The identification of mutations in the T-cell receptor (TCR) signaling pathway that either directly or indirectly affect Ras- and Rho-family GTPases is an emerging theme across PTCL subtypes. This review summarizes the role of GTPases in TCR signaling and highlights the constellation of mutations in this pathway among PTCLs. In particular, focus is given to the functional impact of the mutations and opportunities for targeted therapy. These mutations include activating mutations and gene fusions involving the guanine nucleotide exchange factor, VAV1, as well as activating and dominant negative mutations in the GTPases KRAS and RHOA, respectively. In addition to mutations directly affecting the GTPase pathway, TCR signaling mutations indirectly affecting Ras- and Rho-family GTPases involving genes such as CD28, FYN, LCK, and PLCG1 are also reviewed." @default.
• W2557950677 created "2016-12-08" @default.
• W2557950677 creator A5004446140 @default.
• W2557950677 creator A5043588985 @default.
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• W2557950677 date "2017-01-06" @default.
• W2557950677 modified "2023-10-14" @default.
• W2557950677 title "Genetic alterations affecting GTPases and T-cell receptor signaling in peripheral T-cell lymphomas" @default.
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• W2557950677 doi "https://doi.org/10.1080/21541248.2016.1263718" @default.
• W2557950677 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6343532" @default.
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• W2557950677 hasPublicationYear "2017" @default.
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