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- W2557966057 endingPage "183" @default.
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- W2557966057 abstract "New drugs against Trypanosoma brucei, the causative agent of Human African Trypanosomiasis, are urgently needed to replace the highly toxic and largely ineffective therapies currently used. The trypanosome alternative oxidase (TAO) is an essential and unique mitochondrial protein in these parasites and is absent from mammalian mitochondria, making it an attractive drug target. The structure and function of the protein are now well characterized, with several inhibitors reported in the literature, which show potential as clinical drug candidates. In this review, we provide an update on the functional activity and structural aspects of TAO. We then discuss TAO inhibitors reported to date, problems encountered with in vivo testing of these compounds, and discuss the future of TAO as a therapeutic target." @default.
- W2557966057 created "2016-12-08" @default.
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- W2557966057 date "2016-11-29" @default.
- W2557966057 modified "2023-09-25" @default.
- W2557966057 title "The trypanosome alternative oxidase: a potential drug target?" @default.
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- W2557966057 doi "https://doi.org/10.1017/s0031182016002109" @default.
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