FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2557989406> ?p ?o ?g. }

• W2557989406 endingPage "774" @default.
• W2557989406 startingPage "762" @default.
• W2557989406 abstract "Current models of bacterial homologous recombination (HR) posit that extensive resection of a DNA double-strand break (DSB) by a multisubunit helicase-nuclease machine (e.g. RecBCD, AddAB or AdnAB) generates the requisite 3' single-strand DNA substrate for RecA-mediated strand invasion. AdnAB, the helicase-nuclease implicated in mycobacterial HR, consists of two subunits, AdnA and AdnB, each composed of an N-terminal ATPase domain and a C-terminal nuclease domain. DSB unwinding by AdnAB in vitro is stringently dependent on the ATPase activity of the 'lead' AdnB motor translocating on the 3' ssDNA strand, but not on the putative 'lagging' AdnA ATPase. Here, we queried genetically which activities of AdnAB are pertinent to its role in HR and DNA damage repair in vivo by inactivating each of the four catalytic domains. Complete nuclease-dead AdnAB enzyme can sustain recombination in vivo, as long as its AdnB motor is intact and RecO and RecR are available. We conclude that AdnAB's processive DSB unwinding activity suffices for AdnAB function in HR. Albeit not excluding the agency of a backup nuclease, our findings suggest that mycobacterial HR can proceed via DSB unwinding and protein capture of the displaced 3'-OH single strand, without a need for extensive end-resection." @default.
• W2557989406 created "2016-12-08" @default.
• W2557989406 creator A5014112082 @default.
• W2557989406 creator A5039239105 @default.
• W2557989406 creator A5064984341 @default.
• W2557989406 creator A5073166748 @default.
• W2557989406 date "2016-11-29" @default.
• W2557989406 modified "2023-10-15" @default.
• W2557989406 title "Homologous recombination mediated by the mycobacterial AdnAB helicase without end resection by the AdnAB nucleases" @default.
• W2557989406 cites W141867739 @default.
• W2557989406 cites W1542116187 @default.
• W2557989406 cites W1767234374 @default.
• W2557989406 cites W1845344230 @default.
• W2557989406 cites W1878647250 @default.
• W2557989406 cites W1934542416 @default.
• W2557989406 cites W1960608041 @default.
• W2557989406 cites W1964315457 @default.
• W2557989406 cites W1978846042 @default.
• W2557989406 cites W1984981055 @default.
• W2557989406 cites W1993026474 @default.
• W2557989406 cites W1995823295 @default.
• W2557989406 cites W2009285571 @default.
• W2557989406 cites W2012095700 @default.
• W2557989406 cites W2024327795 @default.
• W2557989406 cites W2029771727 @default.
• W2557989406 cites W2048033859 @default.
• W2557989406 cites W2064049133 @default.
• W2557989406 cites W2069326347 @default.
• W2557989406 cites W2070461581 @default.
• W2557989406 cites W2078380674 @default.
• W2557989406 cites W2090817971 @default.
• W2557989406 cites W2094898086 @default.
• W2557989406 cites W2106226576 @default.
• W2557989406 cites W2116201777 @default.
• W2557989406 cites W2135112075 @default.
• W2557989406 cites W2137816917 @default.
• W2557989406 cites W2139486841 @default.
• W2557989406 cites W2142246190 @default.
• W2557989406 cites W2145304961 @default.
• W2557989406 cites W2145532900 @default.
• W2557989406 cites W2152881342 @default.
• W2557989406 cites W2153556669 @default.
• W2557989406 cites W2161241445 @default.
• W2557989406 cites W2164333605 @default.
• W2557989406 cites W2232707840 @default.
• W2557989406 cites W2394483225 @default.
• W2557989406 cites W4249952782 @default.
• W2557989406 doi "https://doi.org/10.1093/nar/gkw1130" @default.
• W2557989406 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5314763" @default.
• W2557989406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27899634" @default.
• W2557989406 hasPublicationYear "2016" @default.
• W2557989406 type Work @default.
• W2557989406 sameAs 2557989406 @default.
• W2557989406 citedByCount "17" @default.
• W2557989406 countsByYear W25579894062017 @default.
• W2557989406 countsByYear W25579894062019 @default.
• W2557989406 countsByYear W25579894062020 @default.
• W2557989406 countsByYear W25579894062021 @default.
• W2557989406 countsByYear W25579894062022 @default.
• W2557989406 countsByYear W25579894062023 @default.
• W2557989406 crossrefType "journal-article" @default.
• W2557989406 hasAuthorship W2557989406A5014112082 @default.
• W2557989406 hasAuthorship W2557989406A5039239105 @default.
• W2557989406 hasAuthorship W2557989406A5064984341 @default.
• W2557989406 hasAuthorship W2557989406A5073166748 @default.
• W2557989406 hasBestOaLocation W25579894061 @default.
• W2557989406 hasConcept C102744134 @default.
• W2557989406 hasConcept C104317684 @default.
• W2557989406 hasConcept C122917832 @default.
• W2557989406 hasConcept C134935766 @default.
• W2557989406 hasConcept C153911025 @default.
• W2557989406 hasConcept C161223559 @default.
• W2557989406 hasConcept C174742784 @default.
• W2557989406 hasConcept C2777028655 @default.
• W2557989406 hasConcept C2777271071 @default.
• W2557989406 hasConcept C54355233 @default.
• W2557989406 hasConcept C552990157 @default.
• W2557989406 hasConcept C67705224 @default.
• W2557989406 hasConcept C86803240 @default.
• W2557989406 hasConcept C95444343 @default.
• W2557989406 hasConceptScore W2557989406C102744134 @default.
• W2557989406 hasConceptScore W2557989406C104317684 @default.
• W2557989406 hasConceptScore W2557989406C122917832 @default.
• W2557989406 hasConceptScore W2557989406C134935766 @default.
• W2557989406 hasConceptScore W2557989406C153911025 @default.
• W2557989406 hasConceptScore W2557989406C161223559 @default.
• W2557989406 hasConceptScore W2557989406C174742784 @default.
• W2557989406 hasConceptScore W2557989406C2777028655 @default.
• W2557989406 hasConceptScore W2557989406C2777271071 @default.
• W2557989406 hasConceptScore W2557989406C54355233 @default.
• W2557989406 hasConceptScore W2557989406C552990157 @default.
• W2557989406 hasConceptScore W2557989406C67705224 @default.
• W2557989406 hasConceptScore W2557989406C86803240 @default.
• W2557989406 hasConceptScore W2557989406C95444343 @default.
• W2557989406 hasIssue "2" @default.
• W2557989406 hasLocation W25579894061 @default.
• W2557989406 hasLocation W25579894062 @default.
• W2557989406 hasLocation W25579894063 @default.

• next