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• W2558072493 abstract "Background: Psoriasis, an inflammatory disease of skin, shares many immunological features with other complex disorders such as cardiovascular disease, metabolic syndrome and depression. Metabolic syndrome is a cluster of risk factors including central obesity, atherogenic dyslipidaemia, hypertension and glucose intolerance. It is a strong predictor of cardiovascular diseases, diabetes and stroke. Aim: To investigate the prevalence of metabolic syndrome in patients with psoriasis. Methods: It was a prospective, hospital based case-control study of 60 patients with moderate to severe psoriasis having BSAI>10% and PASI>10 and 30 age matched controls having minor skin ailments. Venous samples were taken at the enrolment visit after the subjects had fasted overnight (at least 8 h). Serum cholesterol and triglycerides were measured with enzymatic procedures. Plasma glucose was measured using a glucose oxidase method. Metabolic syndrome was diagnosed by the presence of three or more criteria of the modified version of National Cholesterol Education Programme’s Adult Panel III (ATP III). Statistical analysis of the data was done using statistical processing software (SPSS-17). Results: Psoriatic patients had mean disease duration of 8.16±8.30 years, mean BSAI was 41.88±15.803, mean PASI score was 17.606±6.831 and mean onset of age of psoriasis was 31.41±13.415. Metabolic syndrome was significantly more common in psoriatic patients than in controls [15 (25%) vs 1 (3.3%), odds ratio (OR) = 9.667, P<0.05]. Psoriatic patients also had a significantly higher prevalence of hypertriglyceridemia [26/60 (43.3%) vs. 4/30 (13.3%) odds ratio (OR) = 4.971; P<0.01] and arterial hypertension [28/60 (46.6%) vs. 4/30 (13.3%); P<0.01]." @default.
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• W2558072493 date "2011-01-01" @default.
• W2558072493 modified "2023-09-27" @default.
• W2558072493 title "An insight into relationship between psoriasis and metabolic syndrome" @default.
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