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• W2558084908 abstract "In this study, we report the preparation of nano-hydroxyapatite (nHAp) incorporated poly(methyl methacrylate) (PMMA) scaffolds by conjugated thermal induced phase separation (TIPS) and wet-chemical approach, which essentially facilitates the enhancement of both mechanical as well as biological properties of the scaffolds. The dissolution of PMMA was accomplished by acetone (Ace scaffold), ethanol-water (E-W scaffold) and isopropanol-water (I-W scaffold) mixtures as solvents. The existence of nHAp in PMMA matrix was investigated systematically. The higher degree of porous architecture was achieved from Ace scaffolds compared to both I-W and E-W scaffolds. On the other hand, the dense porous architecture of the I-W scaffold exhibited superior hardness and compressive strength than that of the Ace and E-W scaffolds. All the fabricated samples demonstrated enhanced in vitro bioactivity with respect to increasing immersion period as a result of flower-like in vitro apatite layer formation. The MTT assay was carried out for 1 day and 3 day culture using Saos-2 osteoblast-like cells, which showed better cell proliferation with increasing culture period owing to the interconnected pore architecture of scaffolds and the rational hemocompatibility as per the ASTM standard F756-00." @default.
• W2558084908 created "2016-12-08" @default.
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• W2558084908 date "2017-06-01" @default.
• W2558084908 modified "2023-10-01" @default.
• W2558084908 title "A novel nano-hydroxyapatite — PMMA hybrid scaffolds adopted by conjugated thermal induced phase separation (TIPS) and wet-chemical approach: Analysis of its mechanical and biological properties" @default.
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• W2558084908 doi "https://doi.org/10.1016/j.msec.2016.12.133" @default.
• W2558084908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28415457" @default.
• W2558084908 hasPublicationYear "2017" @default.
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