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• W2558094424 startingPage "e0164489" @default.
• W2558094424 abstract "The downregulation of blood monocyte HLA-DR expression also occurs in tissue infiltrative cells in a context of acute clinical inflammation, especially sepsis. This context favors the development of secondary infections and results from various mechanisms. Little is known about HLA-DR expression on bone marrow (BM) cells of the monocyte lineage, the source of circulating monocytes. This study analyzed the BM HLA-DR expression in ICU patients compared to BM monocytes from non-ICU patients and to blood monocytes of control healthy donors. A potential dysfunction of myeloid differentiation was investigated in a sub-population of these ICU patients to characterize the phenotype of the immature forms of monocytes and granulocytes in BM.BM and blood were drawn from 33 ICU and 9 non-ICU patients having a BM analysis to precise the etiology of abnormal low count in blood cells. The data were compared with blood cells of 28 control donors. Flow cytometry was used for both HLA-DR expression and phenotyping of immature forms of monocytes and granulocytes. HLA-DR expression was downregulated in both blood and BM monocyte in ICU patients compared to BM of non-ICU patients and blood of control donors. Amplitude of HLA-DR downregulation was comparable in septic and non-septic ICU patients. The phenotype of immature forms of monocytes and granulocytes in BM (n = 11) did not show abnormal myeloid (monocyte + granulocyte) differentiation.The downregulation of HLA-DR in BM monocyte lineage is present in ICU patients without major changes in myeloid cells. It may result from a regulation mediated by soluble and/or neuro-endocrine factors present in BM cell microenvironment." @default.
• W2558094424 created "2016-12-08" @default.
• W2558094424 creator A5040713731 @default.
• W2558094424 creator A5073999714 @default.
• W2558094424 creator A5082842955 @default.
• W2558094424 date "2016-11-28" @default.
• W2558094424 modified "2023-09-30" @default.
• W2558094424 title "Downregulation of Blood Monocyte HLA-DR in ICU Patients Is Also Present in Bone Marrow Cells" @default.
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• W2558094424 doi "https://doi.org/10.1371/journal.pone.0164489" @default.
• W2558094424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5125574" @default.
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• W2558094424 hasPublicationYear "2016" @default.
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