FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2558205657> ?p ?o ?g. }

• W2558205657 endingPage "141" @default.
• W2558205657 startingPage "134" @default.
• W2558205657 abstract "In addition to protein synthesis, protein degradation or protein cleavage may be necessary for intermediate (ITM) and long-term memory (LTM) to remove molecular constraints, facilitate persistent kinase activity and modulate synaptic plasticity. Calpains, a family of conserved calcium dependent cysteine proteases, modulate synaptic function through protein cleavage. We used the marine mollusk Aplysia californica to investigate the in vivo role of calpains during intermediate and long-term operant memory formation using the learning that food is inedible (LFI) paradigm. A single LFI training session, in which the animal associates a specific netted seaweed with the failure to swallow, generates short (30min), intermediate (4-6h) and long-term (24h) memory. Using the calpain inhibitors calpeptin and MDL-28170, we found that ITM requires calpain activity for induction and consolidation similar to the previously reported requirements for persistent protein kinase C activity in intermediate-term LFI memory. The induction of LTM also required calpain activity. In contrast to ITM, calpain activity was not necessary for the molecular consolidation of LTM. Surprisingly, six hours after LFI training we found that calpain activity was necessary for LTM, although this is a time at which neither persistent PKC activity nor protein synthesis is required for the maintenance of long-term LFI memory. These results demonstrate that calpains function in multiple roles in vivo during associative memory formation." @default.
• W2558205657 created "2016-12-08" @default.
• W2558205657 creator A5024758427 @default.
• W2558205657 creator A5030291690 @default.
• W2558205657 creator A5032489445 @default.
• W2558205657 creator A5050886015 @default.
• W2558205657 creator A5063111151 @default.
• W2558205657 creator A5066403083 @default.
• W2558205657 date "2017-01-01" @default.
• W2558205657 modified "2023-09-24" @default.
• W2558205657 title "Differential role of calpain-dependent protein cleavage in intermediate and long-term operant memory in Aplysia" @default.
• W2558205657 cites W1509229130 @default.
• W2558205657 cites W1578803168 @default.
• W2558205657 cites W1627140218 @default.
• W2558205657 cites W1917382590 @default.
• W2558205657 cites W1947065403 @default.
• W2558205657 cites W1965283405 @default.
• W2558205657 cites W1969546704 @default.
• W2558205657 cites W1971095698 @default.
• W2558205657 cites W1973317044 @default.
• W2558205657 cites W1974346374 @default.
• W2558205657 cites W1977021131 @default.
• W2558205657 cites W1982250370 @default.
• W2558205657 cites W1982725699 @default.
• W2558205657 cites W1983855055 @default.
• W2558205657 cites W1985927272 @default.
• W2558205657 cites W1987637999 @default.
• W2558205657 cites W1987823613 @default.
• W2558205657 cites W1990523450 @default.
• W2558205657 cites W1995561104 @default.
• W2558205657 cites W1996979978 @default.
• W2558205657 cites W1998966218 @default.
• W2558205657 cites W1999899901 @default.
• W2558205657 cites W2002044194 @default.
• W2558205657 cites W2011131384 @default.
• W2558205657 cites W2024249768 @default.
• W2558205657 cites W2028474863 @default.
• W2558205657 cites W2028607803 @default.
• W2558205657 cites W2031160794 @default.
• W2558205657 cites W2035749731 @default.
• W2558205657 cites W2040816855 @default.
• W2558205657 cites W2045139373 @default.
• W2558205657 cites W2051238023 @default.
• W2558205657 cites W2053432256 @default.
• W2558205657 cites W2058851330 @default.
• W2558205657 cites W2059927418 @default.
• W2558205657 cites W2062147078 @default.
• W2558205657 cites W2070088093 @default.
• W2558205657 cites W2081863440 @default.
• W2558205657 cites W2089922048 @default.
• W2558205657 cites W2092893243 @default.
• W2558205657 cites W2099220104 @default.
• W2558205657 cites W2100076633 @default.
• W2558205657 cites W2109552347 @default.
• W2558205657 cites W2111611651 @default.
• W2558205657 cites W2124267367 @default.
• W2558205657 cites W2127620502 @default.
• W2558205657 cites W2129693041 @default.
• W2558205657 cites W2136879066 @default.
• W2558205657 cites W2141777864 @default.
• W2558205657 cites W2148348802 @default.
• W2558205657 cites W2151078743 @default.
• W2558205657 cites W2157485339 @default.
• W2558205657 cites W2160720263 @default.
• W2558205657 cites W2161409269 @default.
• W2558205657 cites W2264082276 @default.
• W2558205657 cites W2275386476 @default.
• W2558205657 cites W2346760531 @default.
• W2558205657 cites W29354876 @default.
• W2558205657 cites W807957883 @default.
• W2558205657 doi "https://doi.org/10.1016/j.nlm.2016.11.018" @default.
• W2558205657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6179366" @default.
• W2558205657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27913293" @default.
• W2558205657 hasPublicationYear "2017" @default.
• W2558205657 type Work @default.
• W2558205657 sameAs 2558205657 @default.
• W2558205657 citedByCount "5" @default.
• W2558205657 countsByYear W25582056572017 @default.
• W2558205657 countsByYear W25582056572018 @default.
• W2558205657 countsByYear W25582056572022 @default.
• W2558205657 crossrefType "journal-article" @default.
• W2558205657 hasAuthorship W2558205657A5024758427 @default.
• W2558205657 hasAuthorship W2558205657A5030291690 @default.
• W2558205657 hasAuthorship W2558205657A5032489445 @default.
• W2558205657 hasAuthorship W2558205657A5050886015 @default.
• W2558205657 hasAuthorship W2558205657A5063111151 @default.
• W2558205657 hasAuthorship W2558205657A5066403083 @default.
• W2558205657 hasBestOaLocation W25582056572 @default.
• W2558205657 hasConcept C169760540 @default.
• W2558205657 hasConcept C169900460 @default.
• W2558205657 hasConcept C170493617 @default.
• W2558205657 hasConcept C181199279 @default.
• W2558205657 hasConcept C182220744 @default.
• W2558205657 hasConcept C185592680 @default.
• W2558205657 hasConcept C24590219 @default.
• W2558205657 hasConcept C2778178740 @default.
• W2558205657 hasConcept C2781161787 @default.
• W2558205657 hasConcept C48455012 @default.

• next