Matches in SemOpenAlex for { <https://semopenalex.org/work/W2558414873> ?p ?o ?g. }
- W2558414873 endingPage "203" @default.
- W2558414873 startingPage "194" @default.
- W2558414873 abstract "Using sea urchin embryos, we demonstrate that the MEK/MAPK/ERK cascade is essential for the proper progression of the cell cycle. Activation of a limited fraction of MAPK/ERK is required between S-phase and M-phase. Neither DNA replication nor CDK1 activation are impacted by the inhibition of this small active MAPK/ERK fraction. Nonetheless, the chromatin and spindle organisations are profoundly altered. Early morphological disorders induced by the absence of MAPK/ERK activation are correlated with an important inhibition of global protein synthesis and modification in the cyclin B accumulation profile. After appearance of morphological disorders, there is an increase in the level of the inhibitor of protein synthesis, 4E-BP, and, ultimately, an activation of the spindle checkpoint. Altogether, our results suggest that MAPK/ERK activity is required for the synthesis of (a) protein(s) implicated in an early step of chromatin /microtubule attachment. If this MAPK/ERK-dependent step is not achieved, the cell activates a new checkpoint mechanism, involving the reappearance of 4E-BP that maintains a low level of protein translation, thus saving cellular energy." @default.
- W2558414873 created "2016-12-08" @default.
- W2558414873 creator A5014458386 @default.
- W2558414873 creator A5023269406 @default.
- W2558414873 creator A5051231551 @default.
- W2558414873 creator A5054476882 @default.
- W2558414873 creator A5072525622 @default.
- W2558414873 date "2017-01-01" @default.
- W2558414873 modified "2023-10-16" @default.
- W2558414873 title "MAPK/ERK activity is required for the successful progression of mitosis in sea urchin embryos" @default.
- W2558414873 cites W1886278373 @default.
- W2558414873 cites W1965756219 @default.
- W2558414873 cites W1967039423 @default.
- W2558414873 cites W1983833034 @default.
- W2558414873 cites W1989730199 @default.
- W2558414873 cites W1990382556 @default.
- W2558414873 cites W1995254753 @default.
- W2558414873 cites W2004114217 @default.
- W2558414873 cites W2011717893 @default.
- W2558414873 cites W2011817914 @default.
- W2558414873 cites W2012653902 @default.
- W2558414873 cites W2018896819 @default.
- W2558414873 cites W2023363172 @default.
- W2558414873 cites W2034556762 @default.
- W2558414873 cites W2037728125 @default.
- W2558414873 cites W2038696352 @default.
- W2558414873 cites W2046822015 @default.
- W2558414873 cites W2048083639 @default.
- W2558414873 cites W2048206573 @default.
- W2558414873 cites W2077007828 @default.
- W2558414873 cites W2080828132 @default.
- W2558414873 cites W2080987500 @default.
- W2558414873 cites W2089353165 @default.
- W2558414873 cites W2092835016 @default.
- W2558414873 cites W2100837269 @default.
- W2558414873 cites W2101108802 @default.
- W2558414873 cites W2107495112 @default.
- W2558414873 cites W2118655119 @default.
- W2558414873 cites W2122966009 @default.
- W2558414873 cites W2132247435 @default.
- W2558414873 cites W2133435867 @default.
- W2558414873 cites W2159844006 @default.
- W2558414873 cites W2164085341 @default.
- W2558414873 cites W2300503766 @default.
- W2558414873 doi "https://doi.org/10.1016/j.ydbio.2016.11.018" @default.
- W2558414873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27913220" @default.
- W2558414873 hasPublicationYear "2017" @default.
- W2558414873 type Work @default.
- W2558414873 sameAs 2558414873 @default.
- W2558414873 citedByCount "13" @default.
- W2558414873 countsByYear W25584148732017 @default.
- W2558414873 countsByYear W25584148732018 @default.
- W2558414873 countsByYear W25584148732019 @default.
- W2558414873 countsByYear W25584148732020 @default.
- W2558414873 countsByYear W25584148732021 @default.
- W2558414873 countsByYear W25584148732022 @default.
- W2558414873 crossrefType "journal-article" @default.
- W2558414873 hasAuthorship W2558414873A5014458386 @default.
- W2558414873 hasAuthorship W2558414873A5023269406 @default.
- W2558414873 hasAuthorship W2558414873A5051231551 @default.
- W2558414873 hasAuthorship W2558414873A5054476882 @default.
- W2558414873 hasAuthorship W2558414873A5072525622 @default.
- W2558414873 hasBestOaLocation W25584148731 @default.
- W2558414873 hasConcept C1491633281 @default.
- W2558414873 hasConcept C184235292 @default.
- W2558414873 hasConcept C2909378205 @default.
- W2558414873 hasConcept C29537977 @default.
- W2558414873 hasConcept C54355233 @default.
- W2558414873 hasConcept C552990157 @default.
- W2558414873 hasConcept C57074206 @default.
- W2558414873 hasConcept C83640560 @default.
- W2558414873 hasConcept C86803240 @default.
- W2558414873 hasConcept C93304396 @default.
- W2558414873 hasConcept C95444343 @default.
- W2558414873 hasConceptScore W2558414873C1491633281 @default.
- W2558414873 hasConceptScore W2558414873C184235292 @default.
- W2558414873 hasConceptScore W2558414873C2909378205 @default.
- W2558414873 hasConceptScore W2558414873C29537977 @default.
- W2558414873 hasConceptScore W2558414873C54355233 @default.
- W2558414873 hasConceptScore W2558414873C552990157 @default.
- W2558414873 hasConceptScore W2558414873C57074206 @default.
- W2558414873 hasConceptScore W2558414873C83640560 @default.
- W2558414873 hasConceptScore W2558414873C86803240 @default.
- W2558414873 hasConceptScore W2558414873C93304396 @default.
- W2558414873 hasConceptScore W2558414873C95444343 @default.
- W2558414873 hasFunder F4320322363 @default.
- W2558414873 hasFunder F4320327215 @default.
- W2558414873 hasIssue "2" @default.
- W2558414873 hasLocation W25584148731 @default.
- W2558414873 hasLocation W25584148732 @default.
- W2558414873 hasLocation W25584148733 @default.
- W2558414873 hasLocation W25584148734 @default.
- W2558414873 hasOpenAccess W2558414873 @default.
- W2558414873 hasPrimaryLocation W25584148731 @default.
- W2558414873 hasRelatedWork W1544512904 @default.
- W2558414873 hasRelatedWork W1966199536 @default.
- W2558414873 hasRelatedWork W2004726042 @default.
- W2558414873 hasRelatedWork W2045981880 @default.