FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2558471939> ?p ?o ?g. }

• W2558471939 endingPage "275" @default.
• W2558471939 startingPage "268" @default.
• W2558471939 abstract "Background Our study aimed to investigate the associations between Histamine H4 receptor ( HRH4 ) gene polymorphisms (rs77485247, rs74604924, and rs77041280) and oral H1 antihistamine efficacy for the treatment of allergic rhinitis (AR) patients. Methods A total of 142 AR patients were selected as a case group and 160 healthy individuals were recruited as a control group. Single nucleotide polymorphisms (SNPs) in the HRH4 gene were detected using direct sequencing. Serum immunoglobulin E (IgE), specific IgE, and eosinophil cationic protein (ECP) levels were measured by enzyme‐linked immunosorbent assay (ELISA). Clinical efficacy was evaluated by the visual analogue scale (VAS). The occurrence of adverse reaction was recorded. Results There were significant differences in the distribution frequencies of mutant genotype (TA + AA) and A allele of rs77485247, mutant genotype (AT + TT) and T allele of rs74604924, and mutant genotype (AT + TT) and T allele of rs77041280 between the case and control groups. AR patients with mutant genotype (TA + AA) of rs77485247 and AR patients with mutant genotype (AT + TT) of rs77041280 had higher specific IgE, ECP levels, and VAS scores after treatment and lower incidence of adverse reactions and total effective rate than those with TT genotype and those with AA genotype, respectively. However, for rs74604924, there were no differences was found between AR patients with mutant genotype (AT + TT) and those with AA genotype. Conclusion Our findings provide evidence that HRH4 rs77485247 and rs77041280 polymorphisms may be associated with the risk of AR and the efficacy of H1 antihistamines for the treatment of AR patients." @default.
• W2558471939 created "2016-12-08" @default.
• W2558471939 creator A5022535966 @default.
• W2558471939 creator A5040113832 @default.
• W2558471939 creator A5067730267 @default.
• W2558471939 creator A5073542820 @default.
• W2558471939 creator A5077558876 @default.
• W2558471939 creator A5084405992 @default.
• W2558471939 date "2016-11-26" @default.
• W2558471939 modified "2023-10-16" @default.
• W2558471939 title "<i>Histamine H4 receptor</i>gene polymorphisms: a potential predictor of oral H1 antihistamine efficacy for allergic rhinitis" @default.
• W2558471939 cites W1588269848 @default.
• W2558471939 cites W1727665258 @default.
• W2558471939 cites W1751621284 @default.
• W2558471939 cites W1832849100 @default.
• W2558471939 cites W1913238323 @default.
• W2558471939 cites W1949875798 @default.
• W2558471939 cites W1972599928 @default.
• W2558471939 cites W1993156837 @default.
• W2558471939 cites W2005049880 @default.
• W2558471939 cites W2018087170 @default.
• W2558471939 cites W2054139141 @default.
• W2558471939 cites W2056521778 @default.
• W2558471939 cites W2071996827 @default.
• W2558471939 cites W2087444897 @default.
• W2558471939 cites W2091899538 @default.
• W2558471939 cites W2119723202 @default.
• W2558471939 cites W2136254692 @default.
• W2558471939 cites W2136712715 @default.
• W2558471939 cites W2140957405 @default.
• W2558471939 cites W2145879699 @default.
• W2558471939 cites W2160829003 @default.
• W2558471939 cites W2227889413 @default.
• W2558471939 cites W2331726559 @default.
• W2558471939 cites W4229553561 @default.
• W2558471939 doi "https://doi.org/10.1002/alr.21870" @default.
• W2558471939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27888642" @default.
• W2558471939 hasPublicationYear "2016" @default.
• W2558471939 type Work @default.
• W2558471939 sameAs 2558471939 @default.
• W2558471939 citedByCount "11" @default.
• W2558471939 countsByYear W25584719392018 @default.
• W2558471939 countsByYear W25584719392019 @default.
• W2558471939 countsByYear W25584719392020 @default.
• W2558471939 countsByYear W25584719392021 @default.
• W2558471939 countsByYear W25584719392022 @default.
• W2558471939 countsByYear W25584719392023 @default.
• W2558471939 crossrefType "journal-article" @default.
• W2558471939 hasAuthorship W2558471939A5022535966 @default.
• W2558471939 hasAuthorship W2558471939A5040113832 @default.
• W2558471939 hasAuthorship W2558471939A5067730267 @default.
• W2558471939 hasAuthorship W2558471939A5073542820 @default.
• W2558471939 hasAuthorship W2558471939A5077558876 @default.
• W2558471939 hasAuthorship W2558471939A5084405992 @default.
• W2558471939 hasConcept C104317684 @default.
• W2558471939 hasConcept C1122143 @default.
• W2558471939 hasConcept C126322002 @default.
• W2558471939 hasConcept C135763542 @default.
• W2558471939 hasConcept C141105273 @default.
• W2558471939 hasConcept C143065580 @default.
• W2558471939 hasConcept C153209595 @default.
• W2558471939 hasConcept C159654299 @default.
• W2558471939 hasConcept C180754005 @default.
• W2558471939 hasConcept C203014093 @default.
• W2558471939 hasConcept C207480886 @default.
• W2558471939 hasConcept C2776042228 @default.
• W2558471939 hasConcept C2776880894 @default.
• W2558471939 hasConcept C2777037409 @default.
• W2558471939 hasConcept C37463918 @default.
• W2558471939 hasConcept C54355233 @default.
• W2558471939 hasConcept C71924100 @default.
• W2558471939 hasConcept C86803240 @default.
• W2558471939 hasConcept C90924648 @default.
• W2558471939 hasConceptScore W2558471939C104317684 @default.
• W2558471939 hasConceptScore W2558471939C1122143 @default.
• W2558471939 hasConceptScore W2558471939C126322002 @default.
• W2558471939 hasConceptScore W2558471939C135763542 @default.
• W2558471939 hasConceptScore W2558471939C141105273 @default.
• W2558471939 hasConceptScore W2558471939C143065580 @default.
• W2558471939 hasConceptScore W2558471939C153209595 @default.
• W2558471939 hasConceptScore W2558471939C159654299 @default.
• W2558471939 hasConceptScore W2558471939C180754005 @default.
• W2558471939 hasConceptScore W2558471939C203014093 @default.
• W2558471939 hasConceptScore W2558471939C207480886 @default.
• W2558471939 hasConceptScore W2558471939C2776042228 @default.
• W2558471939 hasConceptScore W2558471939C2776880894 @default.
• W2558471939 hasConceptScore W2558471939C2777037409 @default.
• W2558471939 hasConceptScore W2558471939C37463918 @default.
• W2558471939 hasConceptScore W2558471939C54355233 @default.
• W2558471939 hasConceptScore W2558471939C71924100 @default.
• W2558471939 hasConceptScore W2558471939C86803240 @default.
• W2558471939 hasConceptScore W2558471939C90924648 @default.
• W2558471939 hasFunder F4320335305 @default.
• W2558471939 hasIssue "3" @default.
• W2558471939 hasLocation W25584719391 @default.
• W2558471939 hasLocation W25584719392 @default.
• W2558471939 hasOpenAccess W2558471939 @default.
• W2558471939 hasPrimaryLocation W25584719391 @default.

• next