Matches in SemOpenAlex for { <https://semopenalex.org/work/W2558568353> ?p ?o ?g. }
- W2558568353 abstract "Neutralization of the common p40-subunit of IL-12/23 in psoriasis patients has led to a breakthrough in the management of moderate to severe disease. Aside from neutralizing IL-23, which is thought to be responsible for the curative effect, anti-p40 therapy also interferes with IL-12 signalling and type 1 immunity. Here we dissect the individual contribution of these two cytokines to the formation of psoriatic lesions and understand the effect of therapeutic co-targeting of IL-12 and IL-23 in psoriasis. Using a preclinical model for psoriatic plaque formation we show that IL-12, in contrast to IL-23, has a regulatory function by restraining the invasion of an IL-17-committed γδT (γδT17) cell subset. We discover that IL-12 receptor signalling in keratinocytes initiates a protective transcriptional programme that limits skin inflammation, suggesting that collateral targeting of IL-12 by anti-p40 monoclonal antibodies is counterproductive in the therapy of psoriasis." @default.
- W2558568353 created "2016-12-08" @default.
- W2558568353 creator A5000850950 @default.
- W2558568353 creator A5006632216 @default.
- W2558568353 creator A5010185305 @default.
- W2558568353 creator A5015015906 @default.
- W2558568353 creator A5030739586 @default.
- W2558568353 creator A5034502862 @default.
- W2558568353 creator A5044644707 @default.
- W2558568353 creator A5047171254 @default.
- W2558568353 creator A5051595544 @default.
- W2558568353 creator A5061953860 @default.
- W2558568353 creator A5062930299 @default.
- W2558568353 creator A5069406075 @default.
- W2558568353 creator A5070727803 @default.
- W2558568353 creator A5072236145 @default.
- W2558568353 date "2016-11-28" @default.
- W2558568353 modified "2023-10-04" @default.
- W2558568353 title "IL-12 protects from psoriasiform skin inflammation" @default.
- W2558568353 cites W1479895695 @default.
- W2558568353 cites W1525680491 @default.
- W2558568353 cites W1526112396 @default.
- W2558568353 cites W1573058660 @default.
- W2558568353 cites W1661616496 @default.
- W2558568353 cites W1741681584 @default.
- W2558568353 cites W1898779455 @default.
- W2558568353 cites W1906543170 @default.
- W2558568353 cites W1924457352 @default.
- W2558568353 cites W1939997832 @default.
- W2558568353 cites W1957267795 @default.
- W2558568353 cites W1965306711 @default.
- W2558568353 cites W1966419386 @default.
- W2558568353 cites W1967790310 @default.
- W2558568353 cites W1968797543 @default.
- W2558568353 cites W1971708477 @default.
- W2558568353 cites W1975379640 @default.
- W2558568353 cites W1978824248 @default.
- W2558568353 cites W1981177225 @default.
- W2558568353 cites W1987784314 @default.
- W2558568353 cites W1989702104 @default.
- W2558568353 cites W1997319936 @default.
- W2558568353 cites W1997721794 @default.
- W2558568353 cites W2003425690 @default.
- W2558568353 cites W2004671403 @default.
- W2558568353 cites W2006741811 @default.
- W2558568353 cites W2009219530 @default.
- W2558568353 cites W2015823644 @default.
- W2558568353 cites W2023733075 @default.
- W2558568353 cites W2035310778 @default.
- W2558568353 cites W2040177546 @default.
- W2558568353 cites W2041635511 @default.
- W2558568353 cites W2041820695 @default.
- W2558568353 cites W2045113343 @default.
- W2558568353 cites W2056615300 @default.
- W2558568353 cites W2070826648 @default.
- W2558568353 cites W2076889715 @default.
- W2558568353 cites W2082278363 @default.
- W2558568353 cites W2082280403 @default.
- W2558568353 cites W2082554712 @default.
- W2558568353 cites W2091442391 @default.
- W2558568353 cites W2092374642 @default.
- W2558568353 cites W2097935815 @default.
- W2558568353 cites W2100895591 @default.
- W2558568353 cites W2103018315 @default.
- W2558568353 cites W2107432039 @default.
- W2558568353 cites W2112128505 @default.
- W2558568353 cites W2114104545 @default.
- W2558568353 cites W2115790163 @default.
- W2558568353 cites W2116956799 @default.
- W2558568353 cites W2126162679 @default.
- W2558568353 cites W2127661753 @default.
- W2558568353 cites W2127834887 @default.
- W2558568353 cites W2131478115 @default.
- W2558568353 cites W2133657961 @default.
- W2558568353 cites W2134066780 @default.
- W2558568353 cites W2142529371 @default.
- W2558568353 cites W2145634436 @default.
- W2558568353 cites W2149480742 @default.
- W2558568353 cites W2151545717 @default.
- W2558568353 cites W2152283027 @default.
- W2558568353 cites W2159513688 @default.
- W2558568353 cites W2161580321 @default.
- W2558568353 cites W2161972318 @default.
- W2558568353 cites W2162298266 @default.
- W2558568353 cites W2169456326 @default.
- W2558568353 cites W2322390243 @default.
- W2558568353 cites W2326643498 @default.
- W2558568353 cites W4237627879 @default.
- W2558568353 cites W4239945583 @default.
- W2558568353 cites W4248269869 @default.
- W2558568353 doi "https://doi.org/10.1038/ncomms13466" @default.
- W2558568353 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5133729" @default.
- W2558568353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27892456" @default.
- W2558568353 hasPublicationYear "2016" @default.
- W2558568353 type Work @default.
- W2558568353 sameAs 2558568353 @default.
- W2558568353 citedByCount "138" @default.
- W2558568353 countsByYear W25585683532017 @default.
- W2558568353 countsByYear W25585683532018 @default.
- W2558568353 countsByYear W25585683532019 @default.