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- W2558581816 abstract "Pathogen infections, autoimmune diseases, and chronic inflammatory disorders are associated with systemic antibody responses from the host immune system. Disease-specific antibodies can be important serum biomarkers, but the identification of antigens associated with specific immune reactions is challenging, in particular if complex communities of microorganisms are involved in the disease progression. Despite promising new diagnostic opportunities, the discovery of these serological markers becomes more difficult with increasing complexity of microbial communities. In the present work, we used a metagenomic M13 phage display approach to select immunogenic oligopeptides from the gut microbiome of transgenic mice suffering from chronic ileitis. We constructed three individual metaproteome phage display libraries with a library size of approximately 107 clones each. Using serum antibodies, we selected and validated three oligopeptides that induced specific antibody responses in the mouse model. This proof-of-concept study provides the first successful application of functional metaproteome display for the study of protein-protein interactions and the discovery of potential disease biomarkers." @default.
- W2558581816 created "2016-12-08" @default.
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- W2558581816 date "2016-10-05" @default.
- W2558581816 modified "2023-10-17" @default.
- W2558581816 title "Mining gut microbiome oligopeptides by functional metaproteome display" @default.
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- W2558581816 doi "https://doi.org/10.1038/srep34337" @default.
- W2558581816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5050496" @default.
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- W2558581816 hasPublicationYear "2016" @default.
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