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- W2558604525 abstract "Abstract Introduction: Initiation of warfarin therapy is a clinical challenge. A 10 mg warfarin initiation nomogram was recently validated in a randomized controlled trial. We sought to determine the efficacy and safety of this 10 mg warfarin initiation nomogram in “real-life” daily practice. Methods: A retrospective cohort including all outpatients beginning concurrent treatment with warfarin and low-molecular-weight-heparin (LMWH) over a 24 month period in our Thrombosis Unit was reviewed. Results: 841 patients were included, of them 640 (76.1%) were started on the nomogram. The nomogram was entirely followed in 324 patients (38.5%). The efficacy and safety profile was similar to that observed in the original clinical trial: 86% of patients managed according to the nomogram reached the INR target of 2.0 to 3.0 within 5 days. Mean duration of LMWH treatment was 6.0 ± 1.9 days, and 3.7% of patients had an INR ≥ 5.0 in the first four weeks of treatment. Conclusion: The 10-mg nomogram effectively results into an early therapeutic INR with a good safety profile in “real life” daily practice." @default.
- W2558604525 created "2016-12-08" @default.
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- W2558604525 date "2008-11-16" @default.
- W2558604525 modified "2023-09-27" @default.
- W2558604525 title "Practical Application of the 10 Mg Warfarin Initiation Nomogram" @default.
- W2558604525 doi "https://doi.org/10.1182/blood.v112.11.4054.4054" @default.
- W2558604525 hasPublicationYear "2008" @default.
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