FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2558638935> ?p ?o ?g. }

• W2558638935 endingPage "71" @default.
• W2558638935 startingPage "64" @default.
• W2558638935 abstract "The activation of spinal glial cells (astrocyte and microglia) is reported in patient with complex regional pain syndrome (CRPS). However, the roles of spinal glial activities in the pathophysiology of CRPS are unclear. Here, we explored the roles of spinal astrocyte and microglia and the molecular mechanisms underlying CRPS using a mouse model of chronic post-ischemia pain (CPIP). CPIP injury increased the level of glial fibrillary acidic protein (GFAP, reactive astrocyte biomarker), but had no significant impact on ionized calcium binding adaptor molecule 1 (IBA1, reactive microglia biomarker), in the ipsilateral dorsal horn on post-injury day (PID) 3 when the pain threshold started to reduce significantly. Astrocytic inhibition with fluorocitrate but not microglial inhibition with minocycline attenuated the development of allodynia in CPIP-injured mice, which was concomitant with increased spinal levels of phosphorylated c-jun N-terminal kinase 1/2 (pJNK1/2) on PID 3. Furthermore, the intrathecal administration of SP600125 (JNK inhibitor) prevented the development of allodynia in CPIP-injured mice. Double immunofluorescence staining showed that pJNK1/2 was mainly co-localized with GFAP. Subsequently, increased levels of pJNK1/2 were reversed by intrathecal fluorocitrate. Furthermore, the level of spinal matrix metalloproteinase-2 (MMP2) was increased and mainly expressed in NeuN (neuron biomarker) on PID 3 in the CPIP-injured mice, while intrathecal APR 100 (MMP2 inhibitor) delayed the development of allodynia and decreased spinal levels of GFAP and pJNK1/2 on PID 3. This study shows that activation of astrocyte MMP2/JNK1/2 signaling pathway contributes to the pathogenesis of pain hypersensitivity in the CPIP model." @default.
• W2558638935 created "2016-12-08" @default.
• W2558638935 creator A5007866518 @default.
• W2558638935 creator A5033622056 @default.
• W2558638935 creator A5042213542 @default.
• W2558638935 creator A5049727518 @default.
• W2558638935 creator A5067795175 @default.
• W2558638935 creator A5068110218 @default.
• W2558638935 creator A5071051054 @default.
• W2558638935 creator A5082633022 @default.
• W2558638935 date "2017-02-01" @default.
• W2558638935 modified "2023-09-30" @default.
• W2558638935 title "Astrocyte contributes to pain development via MMP2-JNK1/2 signaling in a mouse model of complex regional pain syndrome" @default.
• W2558638935 cites W1964153573 @default.
• W2558638935 cites W1971063834 @default.
• W2558638935 cites W1977663897 @default.
• W2558638935 cites W1982210026 @default.
• W2558638935 cites W1982534244 @default.
• W2558638935 cites W1993768285 @default.
• W2558638935 cites W2003141277 @default.
• W2558638935 cites W2009182920 @default.
• W2558638935 cites W2011724047 @default.
• W2558638935 cites W2016560481 @default.
• W2558638935 cites W2021043915 @default.
• W2558638935 cites W2023582479 @default.
• W2558638935 cites W2034575440 @default.
• W2558638935 cites W2036212062 @default.
• W2558638935 cites W2059646315 @default.
• W2558638935 cites W2074190348 @default.
• W2558638935 cites W2075715972 @default.
• W2558638935 cites W2076002566 @default.
• W2558638935 cites W2089253989 @default.
• W2558638935 cites W2091553256 @default.
• W2558638935 cites W2095387649 @default.
• W2558638935 cites W2098040089 @default.
• W2558638935 cites W2110769281 @default.
• W2558638935 cites W2122240267 @default.
• W2558638935 cites W2123128921 @default.
• W2558638935 cites W2135235221 @default.
• W2558638935 cites W2138810871 @default.
• W2558638935 cites W2140441724 @default.
• W2558638935 cites W2142295577 @default.
• W2558638935 cites W2143222346 @default.
• W2558638935 cites W2159059571 @default.
• W2558638935 cites W2168730807 @default.
• W2558638935 cites W2169553008 @default.
• W2558638935 cites W2321122111 @default.
• W2558638935 cites W2404047797 @default.
• W2558638935 doi "https://doi.org/10.1016/j.lfs.2016.11.030" @default.
• W2558638935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27919822" @default.
• W2558638935 hasPublicationYear "2017" @default.
• W2558638935 type Work @default.
• W2558638935 sameAs 2558638935 @default.
• W2558638935 citedByCount "20" @default.
• W2558638935 countsByYear W25586389352017 @default.
• W2558638935 countsByYear W25586389352018 @default.
• W2558638935 countsByYear W25586389352019 @default.
• W2558638935 countsByYear W25586389352021 @default.
• W2558638935 countsByYear W25586389352022 @default.
• W2558638935 countsByYear W25586389352023 @default.
• W2558638935 crossrefType "journal-article" @default.
• W2558638935 hasAuthorship W2558638935A5007866518 @default.
• W2558638935 hasAuthorship W2558638935A5033622056 @default.
• W2558638935 hasAuthorship W2558638935A5042213542 @default.
• W2558638935 hasAuthorship W2558638935A5049727518 @default.
• W2558638935 hasAuthorship W2558638935A5067795175 @default.
• W2558638935 hasAuthorship W2558638935A5068110218 @default.
• W2558638935 hasAuthorship W2558638935A5071051054 @default.
• W2558638935 hasAuthorship W2558638935A5082633022 @default.
• W2558638935 hasConcept C126322002 @default.
• W2558638935 hasConcept C134018914 @default.
• W2558638935 hasConcept C142724271 @default.
• W2558638935 hasConcept C15490471 @default.
• W2558638935 hasConcept C169760540 @default.
• W2558638935 hasConcept C170493617 @default.
• W2558638935 hasConcept C204232928 @default.
• W2558638935 hasConcept C2776914184 @default.
• W2558638935 hasConcept C2777107010 @default.
• W2558638935 hasConcept C2777542381 @default.
• W2558638935 hasConcept C2777883359 @default.
• W2558638935 hasConcept C2779245659 @default.
• W2558638935 hasConcept C2779830541 @default.
• W2558638935 hasConcept C2780495277 @default.
• W2558638935 hasConcept C2780775167 @default.
• W2558638935 hasConcept C2781100881 @default.
• W2558638935 hasConcept C529278444 @default.
• W2558638935 hasConcept C71924100 @default.
• W2558638935 hasConcept C86803240 @default.
• W2558638935 hasConcept C98274493 @default.
• W2558638935 hasConceptScore W2558638935C126322002 @default.
• W2558638935 hasConceptScore W2558638935C134018914 @default.
• W2558638935 hasConceptScore W2558638935C142724271 @default.
• W2558638935 hasConceptScore W2558638935C15490471 @default.
• W2558638935 hasConceptScore W2558638935C169760540 @default.
• W2558638935 hasConceptScore W2558638935C170493617 @default.
• W2558638935 hasConceptScore W2558638935C204232928 @default.
• W2558638935 hasConceptScore W2558638935C2776914184 @default.
• W2558638935 hasConceptScore W2558638935C2777107010 @default.

• next