FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2558730576> ?p ?o ?g. }

• W2558730576 endingPage "129" @default.
• W2558730576 startingPage "119" @default.
• W2558730576 abstract "<b><i>Background:</i></b> Asthma severity and eosinophilia correlate with a deficiency in vitamin D and its active metabolite calcitriol. Calcitriol modulates numerous leukocyte functions, but its effect on eosinophils is not fully understood. We postulated that calcitriol exerts a direct effect on eosinophil biology by modulating cell survival. <b><i>Methods:</i></b> Purified peripheral blood eosinophils from atopic donors were incubated in the presence of calcitriol for up to 14 days with or without IL-5. The effect of calcitriol on eosinophil viability was measured using the annexin-V/propidium iodide flow cytometry assay. We also examined the release of eosinophil peroxidase (EPX) in media using a flow cytometry assay with anti-EPX antibodies, and the enzymatic activity of EPX was measured by an OPD-based colorimetric assay. <b><i>Results:</i></b> We observed that calcitriol sustained cell viability in eosinophils with a concurrent reduction of necrotic cells. This effect was amplified by the addition of IL-5. In parallel, we observed that a physiological dose of calcitriol (10 n<smlcap>M</smlcap>) significantly reduced eosinophil necrosis and cytolytic release of EPX in media when coincubated with IL-5. <b><i>Conclusion:</i></b> These results suggest that calcitriol may exert a direct effect on eosinophils by reducing necrosis and the cytolytic release of inflammatory mediators like EPX." @default.
• W2558730576 created "2016-12-08" @default.
• W2558730576 creator A5028675249 @default.
• W2558730576 creator A5050734459 @default.
• W2558730576 creator A5058201453 @default.
• W2558730576 creator A5064717671 @default.
• W2558730576 creator A5089365273 @default.
• W2558730576 date "2016-01-01" @default.
• W2558730576 modified "2023-10-14" @default.
• W2558730576 title "Calcitriol Reduces Eosinophil Necrosis Which Leads to the Diminished Release of Cytotoxic Granules" @default.
• W2558730576 cites W1504941592 @default.
• W2558730576 cites W1548718770 @default.
• W2558730576 cites W1594507905 @default.
• W2558730576 cites W1645379154 @default.
• W2558730576 cites W1786797005 @default.
• W2558730576 cites W1963128175 @default.
• W2558730576 cites W1964182229 @default.
• W2558730576 cites W1966589045 @default.
• W2558730576 cites W1970464996 @default.
• W2558730576 cites W1987355514 @default.
• W2558730576 cites W1988468469 @default.
• W2558730576 cites W1994101665 @default.
• W2558730576 cites W1996596237 @default.
• W2558730576 cites W2000996770 @default.
• W2558730576 cites W2003084114 @default.
• W2558730576 cites W2003984174 @default.
• W2558730576 cites W2004981536 @default.
• W2558730576 cites W2008719700 @default.
• W2558730576 cites W2009016013 @default.
• W2558730576 cites W2010232855 @default.
• W2558730576 cites W2011382880 @default.
• W2558730576 cites W2013125458 @default.
• W2558730576 cites W2016875740 @default.
• W2558730576 cites W2017215076 @default.
• W2558730576 cites W2024080191 @default.
• W2558730576 cites W2033775274 @default.
• W2558730576 cites W2038208335 @default.
• W2558730576 cites W2042565697 @default.
• W2558730576 cites W2044696993 @default.
• W2558730576 cites W2055203083 @default.
• W2558730576 cites W2068042695 @default.
• W2558730576 cites W2078052241 @default.
• W2558730576 cites W2084859214 @default.
• W2558730576 cites W2086948000 @default.
• W2558730576 cites W2124070987 @default.
• W2558730576 cites W2145464760 @default.
• W2558730576 cites W2152426279 @default.
• W2558730576 cites W2158560989 @default.
• W2558730576 cites W2166763897 @default.
• W2558730576 cites W2170244650 @default.
• W2558730576 cites W4230976467 @default.
• W2558730576 doi "https://doi.org/10.1159/000450951" @default.
• W2558730576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27902981" @default.
• W2558730576 hasPublicationYear "2016" @default.
• W2558730576 type Work @default.
• W2558730576 sameAs 2558730576 @default.
• W2558730576 citedByCount "13" @default.
• W2558730576 countsByYear W25587305762017 @default.
• W2558730576 countsByYear W25587305762018 @default.
• W2558730576 countsByYear W25587305762020 @default.
• W2558730576 countsByYear W25587305762021 @default.
• W2558730576 countsByYear W25587305762022 @default.
• W2558730576 countsByYear W25587305762023 @default.
• W2558730576 crossrefType "journal-article" @default.
• W2558730576 hasAuthorship W2558730576A5028675249 @default.
• W2558730576 hasAuthorship W2558730576A5050734459 @default.
• W2558730576 hasAuthorship W2558730576A5058201453 @default.
• W2558730576 hasAuthorship W2558730576A5064717671 @default.
• W2558730576 hasAuthorship W2558730576A5089365273 @default.
• W2558730576 hasBestOaLocation W25587305761 @default.
• W2558730576 hasConcept C124490489 @default.
• W2558730576 hasConcept C126322002 @default.
• W2558730576 hasConcept C134018914 @default.
• W2558730576 hasConcept C185592680 @default.
• W2558730576 hasConcept C190283241 @default.
• W2558730576 hasConcept C203014093 @default.
• W2558730576 hasConcept C2775934118 @default.
• W2558730576 hasConcept C2776042228 @default.
• W2558730576 hasConcept C2776079296 @default.
• W2558730576 hasConcept C2777037409 @default.
• W2558730576 hasConcept C31573885 @default.
• W2558730576 hasConcept C55493867 @default.
• W2558730576 hasConcept C71924100 @default.
• W2558730576 hasConcept C86803240 @default.
• W2558730576 hasConceptScore W2558730576C124490489 @default.
• W2558730576 hasConceptScore W2558730576C126322002 @default.
• W2558730576 hasConceptScore W2558730576C134018914 @default.
• W2558730576 hasConceptScore W2558730576C185592680 @default.
• W2558730576 hasConceptScore W2558730576C190283241 @default.
• W2558730576 hasConceptScore W2558730576C203014093 @default.
• W2558730576 hasConceptScore W2558730576C2775934118 @default.
• W2558730576 hasConceptScore W2558730576C2776042228 @default.
• W2558730576 hasConceptScore W2558730576C2776079296 @default.
• W2558730576 hasConceptScore W2558730576C2777037409 @default.
• W2558730576 hasConceptScore W2558730576C31573885 @default.
• W2558730576 hasConceptScore W2558730576C55493867 @default.
• W2558730576 hasConceptScore W2558730576C71924100 @default.
• W2558730576 hasConceptScore W2558730576C86803240 @default.

• next