FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2558742480> ?p ?o ?g. }

• W2558742480 endingPage "216" @default.
• W2558742480 startingPage "203" @default.
• W2558742480 abstract "Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature of the inflammatory/oxidative state and provide information regarding the progression of clinical disease.MPs were harvested from supernatants of human peripheral blood mononuclear cells in vitro incubated with Tc (control: LPS treated), plasma of seropositive humans with a clinically asymptomatic (CA) or symptomatic (CS) disease state (vs. normal/healthy [NH] controls), and plasma of mice immunized with a protective vaccine before challenge infection (control: unvaccinated/infected). Macrophages (mφs) were incubated with MPs, and we probed the gene expression profile using the inflammatory signaling cascade and cytokine/chemokine arrays, phenotypic markers of mφ activation by flow cytometry, cytokine profile by means of an ELISA and Bioplex assay, and oxidative/nitrosative stress and mitotoxicity by means of colorimetric and fluorometric assays.Tc- and LPS-induced MPs stimulated proliferation, inflammatory gene expression profile, and nitric oxide (∙NO) release in human THP-1 mφs. LPS-MPs were more immunostimulatory than Tc-MPs. Endothelial cells, T lymphocytes, and mφs were the major source of MPs shed in the plasma of chagasic humans and experimentally infected mice. The CS and CA (vs. NH) MPs elicited >2-fold increase in NO and mitochondrial oxidative stress in THP-1 mφs; however, CS (vs. CA) MPs elicited a more pronounced and disease-state-specific inflammatory gene expression profile (IKBKB, NR3C1, and TIRAP vs. CCR4, EGR2, and CCL3), cytokine release (IL-2 + IFN-γ > GCSF), and surface markers of mφ activation (CD14 and CD16). The circulatory MPs of nonvaccinated/infected mice induced 7.5-fold and 40% increases in ∙NO and IFN-γ production, respectively, while these responses were abolished when RAW264.7 mφs were incubated with circulatory MPs of vaccinated/infected mice.Circulating MPs reflect in vivo levels of an oxidative, nitrosative, and inflammatory state, and have potential utility in evaluating disease severity and the efficacy of vaccines and drug therapies against CCM." @default.
• W2558742480 created "2016-12-08" @default.
• W2558742480 creator A5000330351 @default.
• W2558742480 creator A5014957200 @default.
• W2558742480 creator A5037237697 @default.
• W2558742480 creator A5043015474 @default.
• W2558742480 creator A5048364189 @default.
• W2558742480 creator A5065183058 @default.
• W2558742480 creator A5066284750 @default.
• W2558742480 creator A5066453546 @default.
• W2558742480 creator A5078219632 @default.
• W2558742480 creator A5084252170 @default.
• W2558742480 date "2016-12-01" @default.
• W2558742480 modified "2023-10-06" @default.
• W2558742480 title "Gene Expression Profiling and Functional Characterization of Macrophages in Response to Circulatory Microparticles Produced during <b><i>Trypanosoma cruzi</i></b> Infection and Chagas Disease" @default.
• W2558742480 cites W1554926950 @default.
• W2558742480 cites W1690540890 @default.
• W2558742480 cites W1808198581 @default.
• W2558742480 cites W1971350188 @default.
• W2558742480 cites W1973508044 @default.
• W2558742480 cites W1979245971 @default.
• W2558742480 cites W1994070088 @default.
• W2558742480 cites W2002186895 @default.
• W2558742480 cites W2009662910 @default.
• W2558742480 cites W2011847934 @default.
• W2558742480 cites W2021531572 @default.
• W2558742480 cites W2026016627 @default.
• W2558742480 cites W2031640770 @default.
• W2558742480 cites W2038480224 @default.
• W2558742480 cites W2043706020 @default.
• W2558742480 cites W2046784759 @default.
• W2558742480 cites W2047065652 @default.
• W2558742480 cites W2051821086 @default.
• W2558742480 cites W2055269298 @default.
• W2558742480 cites W2057334484 @default.
• W2558742480 cites W2063503143 @default.
• W2558742480 cites W2088988575 @default.
• W2558742480 cites W2097558240 @default.
• W2558742480 cites W2105397872 @default.
• W2558742480 cites W2106196303 @default.
• W2558742480 cites W2116510943 @default.
• W2558742480 cites W2118011591 @default.
• W2558742480 cites W2130568249 @default.
• W2558742480 cites W2140149922 @default.
• W2558742480 cites W2149976637 @default.
• W2558742480 cites W2153473311 @default.
• W2558742480 cites W2163269000 @default.
• W2558742480 cites W2166953540 @default.
• W2558742480 cites W2188901027 @default.
• W2558742480 cites W2267418655 @default.
• W2558742480 cites W2278635421 @default.
• W2558742480 cites W2322471444 @default.
• W2558742480 doi "https://doi.org/10.1159/000451055" @default.
• W2558742480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5330851" @default.
• W2558742480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27902980" @default.
• W2558742480 hasPublicationYear "2016" @default.
• W2558742480 type Work @default.
• W2558742480 sameAs 2558742480 @default.
• W2558742480 citedByCount "29" @default.
• W2558742480 countsByYear W25587424802018 @default.
• W2558742480 countsByYear W25587424802019 @default.
• W2558742480 countsByYear W25587424802020 @default.
• W2558742480 countsByYear W25587424802021 @default.
• W2558742480 countsByYear W25587424802022 @default.
• W2558742480 countsByYear W25587424802023 @default.
• W2558742480 crossrefType "journal-article" @default.
• W2558742480 hasAuthorship W2558742480A5000330351 @default.
• W2558742480 hasAuthorship W2558742480A5014957200 @default.
• W2558742480 hasAuthorship W2558742480A5037237697 @default.
• W2558742480 hasAuthorship W2558742480A5043015474 @default.
• W2558742480 hasAuthorship W2558742480A5048364189 @default.
• W2558742480 hasAuthorship W2558742480A5065183058 @default.
• W2558742480 hasAuthorship W2558742480A5066284750 @default.
• W2558742480 hasAuthorship W2558742480A5066453546 @default.
• W2558742480 hasAuthorship W2558742480A5078219632 @default.
• W2558742480 hasAuthorship W2558742480A5084252170 @default.
• W2558742480 hasBestOaLocation W25587424801 @default.
• W2558742480 hasConcept C112418997 @default.
• W2558742480 hasConcept C13373296 @default.
• W2558742480 hasConcept C134018914 @default.
• W2558742480 hasConcept C136764020 @default.
• W2558742480 hasConcept C137061746 @default.
• W2558742480 hasConcept C153911025 @default.
• W2558742480 hasConcept C17991360 @default.
• W2558742480 hasConcept C202751555 @default.
• W2558742480 hasConcept C203014093 @default.
• W2558742480 hasConcept C2776151105 @default.
• W2558742480 hasConcept C2776914184 @default.
• W2558742480 hasConcept C2777625466 @default.
• W2558742480 hasConcept C2778690821 @default.
• W2558742480 hasConcept C41008148 @default.
• W2558742480 hasConcept C55493867 @default.
• W2558742480 hasConcept C71928629 @default.
• W2558742480 hasConcept C86803240 @default.
• W2558742480 hasConceptScore W2558742480C112418997 @default.
• W2558742480 hasConceptScore W2558742480C13373296 @default.
• W2558742480 hasConceptScore W2558742480C134018914 @default.
• W2558742480 hasConceptScore W2558742480C136764020 @default.

• next