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- W2558779919 endingPage "36" @default.
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- W2558779919 abstract "Microbial resistance against antibiotics is a serious threat to the effective treatment of infectious diseases. Several mechanisms exist through which microorganisms can develop resistance against antimicrobial drugs, of which the overexpression of genes to produce efflux pumps is a major concern. Several efflux transporters have been identified in microorganisms, which infer resistance against specific antibiotics and even multidrug resistance. Areas covered: This paper focuses on microbial resistance against antibiotics by means of the mechanism of efflux and gives a critical overview of studies conducted to overcome this problem by combining efflux pump inhibitors with antibiotics. Information was obtained from a literature search done with MEDLINE, Pubmed, Scopus, ScienceDirect, OneSearch and EBSCO host. Expert opinion: Efflux as a mechanism of multidrug resistance has presented a platform for improved efficacy against resistant microorganisms by co-administration of efflux pump inhibitors with antimicrobial agents. Although proof of concept has been shown for this approach with in vitro experiments, further research is needed to develop more potent inhibitors with low toxicity which is clinically effective." @default.
- W2558779919 created "2016-12-08" @default.
- W2558779919 creator A5006974460 @default.
- W2558779919 creator A5007577109 @default.
- W2558779919 creator A5035358117 @default.
- W2558779919 creator A5058964692 @default.
- W2558779919 creator A5087962768 @default.
- W2558779919 date "2016-12-05" @default.
- W2558779919 modified "2023-10-16" @default.
- W2558779919 title "Efflux as a mechanism of antimicrobial drug resistance in clinical relevant microorganisms: the role of efflux inhibitors" @default.
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