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- W2558812398 abstract "Cumulative studies showed that taurine (2-aminoethanesulfonic acid) contributes to a variety of physiological events. Transport study suggested the cellular taurine transport in an Na+- and Cl--dependent manner, and the several members of SLC6A family have been shown as taurine transporter. At the inner blood-retinal barrier (BRB), taurine transporter (TauT/SLC6A) is involved in the transport of taurine to the retina from the circulating blood. The involvement of TauT is also suggested in γ-aminobutyric acid (GABA) transport at the inner BRB, and its role is assumed in the elimination of GABA from the retinal interstitial fluid. In the retina, taurine is thought to be a major organic osmolyte, and its influx and efflux through TauT and volume-sensitive organic osmolyte and anion channel (VSOAC) in Müller cells regulate the osmolarity in the retinal microenvironment to maintain a healthy retina. In the liver, hepatocytes take up taurine via GABA transporter 2 (GAT2/SLC6A13, the orthologue of mouse GAT3) expressed at the sinusoidal membrane of periportal hepatocytes, contributing to the metabolism of bile acid. Site-directed mutagenesis study suggests amino acid residues that are crucial in the recognition of substrates by GATs and TauT. The evidence suggests the physiological impact of taurine transporters in tissues." @default.
- W2558812398 created "2016-12-08" @default.
- W2558812398 creator A5062417379 @default.
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- W2558812398 date "2016-01-01" @default.
- W2558812398 modified "2023-10-13" @default.
- W2558812398 title "Impact of SLC6A Transporters in Physiological Taurine Transport at the Blood–Retinal Barrier and in the Liver" @default.
- W2558812398 cites W1488736137 @default.
- W2558812398 cites W1516995650 @default.
- W2558812398 cites W1519991112 @default.
- W2558812398 cites W1550534589 @default.
- W2558812398 cites W1743649030 @default.
- W2558812398 cites W1772557960 @default.
- W2558812398 cites W1816852763 @default.
- W2558812398 cites W1953640327 @default.
- W2558812398 cites W1954700434 @default.
- W2558812398 cites W1967672958 @default.
- W2558812398 cites W1972265008 @default.
- W2558812398 cites W1980741553 @default.
- W2558812398 cites W1983307735 @default.
- W2558812398 cites W1984218699 @default.
- W2558812398 cites W1987834954 @default.
- W2558812398 cites W1993863116 @default.
- W2558812398 cites W1995063014 @default.
- W2558812398 cites W1997815441 @default.
- W2558812398 cites W1999957169 @default.
- W2558812398 cites W2004616733 @default.
- W2558812398 cites W2016095497 @default.
- W2558812398 cites W2019396452 @default.
- W2558812398 cites W2022200746 @default.
- W2558812398 cites W2023638475 @default.
- W2558812398 cites W2028386191 @default.
- W2558812398 cites W2029986566 @default.
- W2558812398 cites W2030857678 @default.
- W2558812398 cites W2031577749 @default.
- W2558812398 cites W2033529123 @default.
- W2558812398 cites W203607958 @default.
- W2558812398 cites W2039923977 @default.
- W2558812398 cites W2040411965 @default.
- W2558812398 cites W2043508649 @default.
- W2558812398 cites W2047527992 @default.
- W2558812398 cites W2053330312 @default.
- W2558812398 cites W2055432157 @default.
- W2558812398 cites W2056119107 @default.
- W2558812398 cites W2057775780 @default.
- W2558812398 cites W2061850933 @default.
- W2558812398 cites W2064225780 @default.
- W2558812398 cites W206616870 @default.
- W2558812398 cites W2068242557 @default.
- W2558812398 cites W2071245542 @default.
- W2558812398 cites W2077498400 @default.
- W2558812398 cites W2078266837 @default.
- W2558812398 cites W2079307415 @default.
- W2558812398 cites W2080877094 @default.
- W2558812398 cites W2081246236 @default.
- W2558812398 cites W2081478301 @default.
- W2558812398 cites W2081639977 @default.
- W2558812398 cites W2082919761 @default.
- W2558812398 cites W2083579589 @default.
- W2558812398 cites W2085137872 @default.
- W2558812398 cites W2085719787 @default.
- W2558812398 cites W2089502287 @default.
- W2558812398 cites W2090596818 @default.
- W2558812398 cites W2091013686 @default.
- W2558812398 cites W2091832338 @default.
- W2558812398 cites W2101099010 @default.
- W2558812398 cites W2104622728 @default.
- W2558812398 cites W2110390774 @default.
- W2558812398 cites W2116123190 @default.
- W2558812398 cites W2131300789 @default.
- W2558812398 cites W2136625498 @default.
- W2558812398 cites W2138018209 @default.
- W2558812398 cites W2139246364 @default.
- W2558812398 cites W2139488349 @default.
- W2558812398 cites W2143189887 @default.
- W2558812398 cites W2153886433 @default.
- W2558812398 cites W2158661778 @default.
- W2558812398 cites W2162542944 @default.
- W2558812398 cites W2164158193 @default.
- W2558812398 cites W2164747501 @default.
- W2558812398 cites W2173087970 @default.
- W2558812398 cites W2186334188 @default.
- W2558812398 cites W2272840428 @default.
- W2558812398 cites W2332563789 @default.
- W2558812398 cites W2341154236 @default.
- W2558812398 cites W2433050399 @default.
- W2558812398 cites W61308083 @default.
- W2558812398 doi "https://doi.org/10.1248/bpb.b16-00597" @default.
- W2558812398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27904033" @default.
- W2558812398 hasPublicationYear "2016" @default.
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