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- W2558819306 abstract "Abstract Alpha-synuclein (α-Syn) is a small presynaptic protein of 140 amino acids. Its pathologic intracellular aggregation within the central nervous system yields protein fibrillar inclusions named Lewy bodies that are the hallmarks of Parkinson’s disease (PD). In solution, pure α-Syn adopts an intrinsically disordered structure and assembles into fibrils that exhibit considerable morphological heterogeneity depending on their assembly conditions. We recently established tightly controlled experimental conditions allowing the assembly of α-Syn into highly homogeneous and pure polymorphs. The latter exhibited differences in their shape, their structure but also in their functional properties. We have conducted an AFM study at high resolution and performed a statistical analysis of fibrillar α-Syn shape and thermal fluctuations to calculate the persistence length to further assess the nanomechanical properties of α-Syn polymorphs. Herein, we demonstrated quantitatively that distinct polymorphs made of the same protein (wild-type α-Syn) show significant differences in their morphology (height, width and periodicity) and physical properties (persistence length, bending rigidity and axial Young’s modulus)." @default.
- W2558819306 created "2016-12-08" @default.
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- W2558819306 date "2016-11-30" @default.
- W2558819306 modified "2023-10-14" @default.
- W2558819306 title "Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein" @default.
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- W2558819306 doi "https://doi.org/10.1038/srep37970" @default.
- W2558819306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5128817" @default.
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