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• W2558879797 endingPage "2801" @default.
• W2558879797 startingPage "2801" @default.
• W2558879797 abstract "<ns4:p>Filamentous fungi have proven to be a better-suited model system than unicellular yeasts in analyses of cellular processes such as polarized growth, exocytosis, endocytosis, and cytoskeleton-based organelle traffic. For example, the filamentous fungus<ns4:italic>Neurospora crassa</ns4:italic>develops a variety of cellular forms. Studying the molecular basis of these forms has led to a better, yet incipient, understanding of polarized growth. Polarity factors as well as Rho GTPases, septins, and a localized delivery of vesicles are the central elements described so far that participate in the shift from isotropic to polarized growth. The growth of the cell wall by apical biosynthesis and remodeling of polysaccharide components is a key process in hyphal morphogenesis. The coordinated action of motor proteins and Rab GTPases mediates the vesicular journey along the hyphae toward the apex, where the exocyst mediates vesicle fusion with the plasma membrane. Cytoplasmic microtubules and actin microfilaments serve as tracks for the transport of vesicular carriers as well as organelles in the tubular cell, contributing to polarization. In addition to exocytosis, endocytosis is required to set and maintain the apical polarity of the cell. Here, we summarize some of the most recent breakthroughs in hyphal morphogenesis and apical growth in<ns4:italic>N. crassa</ns4:italic>and the emerging questions that we believe should be addressed.</ns4:p>" @default.
• W2558879797 created "2016-12-08" @default.
• W2558879797 creator A5007265945 @default.
• W2558879797 creator A5035783880 @default.
• W2558879797 date "2016-11-30" @default.
• W2558879797 modified "2023-10-16" @default.
• W2558879797 title "Hyphal ontogeny in Neurospora crassa: a model organism for all seasons" @default.
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