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- W2558904766 abstract "In this work we present the synthesis, aqueous solubility and stability, hydrolysis by alkaline phosphatase, and in vivo fasciolicidal activity in sheep of a highly water soluble phosphate salt prodrug of triclabendazole (MFR-5). The aqueous solubility of MFR-5 at pH 7 was 88,000-fold that of triclabendazole. MFR-5 showed excellent aqueous stability (>95% after 26 h) at pH 7, making it ideal for developing pharmaceutical compositions in the form of solutions that can easily be hydrolyzed by the enzyme alkaline phosphatase (t = 13.6 s) to liberate the precursor compound. An aqueous solution of MFR-5 administered intramuscularly to sheep at concentrations of 4, 6 and 8 mg/kg presented a fasciolicidal efficiency of 96.5%, 98.4% and 99.2%, respectively. In the in vivo experiments, MFR-5 reduced 100% the excretion of eggs in all of the above concentrations." @default.
- W2558904766 created "2016-12-08" @default.
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- W2558904766 date "2017-02-01" @default.
- W2558904766 modified "2023-10-18" @default.
- W2558904766 title "Novel triclabendazole prodrug: A highly water soluble alternative for the treatment of fasciolosis" @default.
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- W2558904766 doi "https://doi.org/10.1016/j.bmcl.2016.12.004" @default.
- W2558904766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28027870" @default.
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