FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2558906071> ?p ?o ?g. }

• W2558906071 endingPage "352" @default.
• W2558906071 startingPage "347" @default.
• W2558906071 abstract "Objective mTOR inhibitor treatment of solid cancers is associated with mTOR inhibitor‐associated stomatitis ( mIAS ) a common, significant, dose‐limiting toxicity, with aphthous‐like lesions. Our objective was to assess the utility of a new organotypic model in defining mIAS ’ pathogenesis. Materials and methods The effect of everolimus on organotypic human oral mucosa was studied. Sterile specimens were assessed 24 and 48 h after exposure to varying concentrations of everolimus. Morphologic changes and measures of apoptosis, proliferation, and levels of six Th1 and Th2 cytokines were studied. Results Following a 24‐h incubation, concentrations of 500 ng ml −1 of everolimus resulted in histological changes consistent with epithelial injury, disorganization and pre‐ or early apoptosis, increased TUNEL ‐positive staining ( P < 0.05) and reduced PCNA ‐positive staining cells ( P < 0.001) and increased levels of IL ‐6 ( P < 0.0001), IL ‐8 ( P < 0.01), and IFN ‐ γ ( P < 0.09). Conclusions Everolimus elicited epithelial damage manifest by morphologic changes, increased apoptosis, and decreased proliferation with concurrent release of keratinocyte‐derived pro‐inflammatory cytokines in the absence of bacteria. The extent of the effect was concentration and time dependent. These results suggest that mIAS is likely initiated by direct epithelial injury, independent of the microbiome. Keratinocyte cytokine release could likely play a role in accelerating an inflammatory infiltrate." @default.
• W2558906071 created "2016-12-08" @default.
• W2558906071 creator A5016342657 @default.
• W2558906071 creator A5028274750 @default.
• W2558906071 creator A5057373271 @default.
• W2558906071 date "2017-01-13" @default.
• W2558906071 modified "2023-10-04" @default.
• W2558906071 title "On the pathogenesis of mTOR inhibitor-associated stomatitis (mIAS)-studies using an organotypic model of the oral mucosa" @default.
• W2558906071 cites W1512421633 @default.
• W2558906071 cites W1967217802 @default.
• W2558906071 cites W1974418321 @default.
• W2558906071 cites W1990980516 @default.
• W2558906071 cites W1997192168 @default.
• W2558906071 cites W2003670385 @default.
• W2558906071 cites W2009800737 @default.
• W2558906071 cites W2025878509 @default.
• W2558906071 cites W2030982530 @default.
• W2558906071 cites W2041067005 @default.
• W2558906071 cites W2059763061 @default.
• W2558906071 cites W2081985260 @default.
• W2558906071 cites W2088417334 @default.
• W2558906071 cites W2090625783 @default.
• W2558906071 cites W2091627087 @default.
• W2558906071 cites W2117863627 @default.
• W2558906071 cites W2132052921 @default.
• W2558906071 cites W2138416060 @default.
• W2558906071 cites W2146045005 @default.
• W2558906071 cites W2155018172 @default.
• W2558906071 cites W2156564774 @default.
• W2558906071 cites W2169006565 @default.
• W2558906071 cites W2237781459 @default.
• W2558906071 cites W2388770186 @default.
• W2558906071 cites W2469222194 @default.
• W2558906071 cites W2517175971 @default.
• W2558906071 cites W4240042710 @default.
• W2558906071 doi "https://doi.org/10.1111/odi.12616" @default.
• W2558906071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27896917" @default.
• W2558906071 hasPublicationYear "2017" @default.
• W2558906071 type Work @default.
• W2558906071 sameAs 2558906071 @default.
• W2558906071 citedByCount "11" @default.
• W2558906071 countsByYear W25589060712017 @default.
• W2558906071 countsByYear W25589060712018 @default.
• W2558906071 countsByYear W25589060712019 @default.
• W2558906071 countsByYear W25589060712020 @default.
• W2558906071 countsByYear W25589060712021 @default.
• W2558906071 countsByYear W25589060712023 @default.
• W2558906071 crossrefType "journal-article" @default.
• W2558906071 hasAuthorship W2558906071A5016342657 @default.
• W2558906071 hasAuthorship W2558906071A5028274750 @default.
• W2558906071 hasAuthorship W2558906071A5057373271 @default.
• W2558906071 hasConcept C126322002 @default.
• W2558906071 hasConcept C142724271 @default.
• W2558906071 hasConcept C164027704 @default.
• W2558906071 hasConcept C190283241 @default.
• W2558906071 hasConcept C196795494 @default.
• W2558906071 hasConcept C202751555 @default.
• W2558906071 hasConcept C203014093 @default.
• W2558906071 hasConcept C204232928 @default.
• W2558906071 hasConcept C2776914184 @default.
• W2558906071 hasConcept C2777074287 @default.
• W2558906071 hasConcept C2777921159 @default.
• W2558906071 hasConcept C2778690821 @default.
• W2558906071 hasConcept C2779051857 @default.
• W2558906071 hasConcept C2779699572 @default.
• W2558906071 hasConcept C2780942790 @default.
• W2558906071 hasConcept C502942594 @default.
• W2558906071 hasConcept C55493867 @default.
• W2558906071 hasConcept C71924100 @default.
• W2558906071 hasConcept C86554907 @default.
• W2558906071 hasConcept C86803240 @default.
• W2558906071 hasConcept C98274493 @default.
• W2558906071 hasConceptScore W2558906071C126322002 @default.
• W2558906071 hasConceptScore W2558906071C142724271 @default.
• W2558906071 hasConceptScore W2558906071C164027704 @default.
• W2558906071 hasConceptScore W2558906071C190283241 @default.
• W2558906071 hasConceptScore W2558906071C196795494 @default.
• W2558906071 hasConceptScore W2558906071C202751555 @default.
• W2558906071 hasConceptScore W2558906071C203014093 @default.
• W2558906071 hasConceptScore W2558906071C204232928 @default.
• W2558906071 hasConceptScore W2558906071C2776914184 @default.
• W2558906071 hasConceptScore W2558906071C2777074287 @default.
• W2558906071 hasConceptScore W2558906071C2777921159 @default.
• W2558906071 hasConceptScore W2558906071C2778690821 @default.
• W2558906071 hasConceptScore W2558906071C2779051857 @default.
• W2558906071 hasConceptScore W2558906071C2779699572 @default.
• W2558906071 hasConceptScore W2558906071C2780942790 @default.
• W2558906071 hasConceptScore W2558906071C502942594 @default.
• W2558906071 hasConceptScore W2558906071C55493867 @default.
• W2558906071 hasConceptScore W2558906071C71924100 @default.
• W2558906071 hasConceptScore W2558906071C86554907 @default.
• W2558906071 hasConceptScore W2558906071C86803240 @default.
• W2558906071 hasConceptScore W2558906071C98274493 @default.
• W2558906071 hasIssue "3" @default.
• W2558906071 hasLocation W25589060711 @default.
• W2558906071 hasLocation W25589060712 @default.
• W2558906071 hasOpenAccess W2558906071 @default.
• W2558906071 hasPrimaryLocation W25589060711 @default.

• next