Matches in SemOpenAlex for { <https://semopenalex.org/work/W2558984687> ?p ?o ?g. }
- W2558984687 abstract "Animals require molecular signals to determine when to divert resources from somatic functions to reproduction. This decision is vital in animals that reproduce in an all-or-nothing mode, such as bristle worms: females committed to reproduction spend roughly half their body mass for yolk and egg production; following mass spawning, the parents die. An enigmatic brain hormone activity suppresses reproduction. We now identify this hormone as the sesquiterpenoid methylfarnesoate. Methylfarnesoate suppresses transcript levels of the yolk precursor Vitellogenin both in cell culture and in vivo, directly inhibiting a central energy–costly step of reproductive maturation. We reveal that contrary to common assumptions, sesquiterpenoids are ancient animal hormones present in marine and terrestrial lophotrochozoans. In turn, insecticides targeting this pathway suppress vitellogenesis in cultured worm cells. These findings challenge current views of animal hormone evolution, and indicate that non-target species and marine ecosystems are susceptible to commonly used insect larvicides." @default.
- W2558984687 created "2016-12-08" @default.
- W2558984687 creator A5011336519 @default.
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- W2558984687 date "2016-11-29" @default.
- W2558984687 modified "2023-09-25" @default.
- W2558984687 title "Discovery of methylfarnesoate as the annelid brain hormone reveals an ancient role of sesquiterpenoids in reproduction" @default.
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- W2558984687 doi "https://doi.org/10.7554/elife.17126" @default.
- W2558984687 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5127642" @default.
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- W2558984687 hasPublicationYear "2016" @default.
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