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• W2559066614 abstract "Abstract Molecular monitoring of BCR-ABL1 transcripts for patients with chronic myeloid leukemia (CML) is now used to assess response to tyrosine kinase inhibitors (TKIs), including treatment failure that mandates a change of therapy. Therefore, many centers have adopted the molecular technique for measuring BCR-ABL1 and rely on conversion of values to the international reporting scale for appropriate clinical interpretation. However, the technique has a degree of inherent variability despite standardized procedures, which means care should be taken by the clinician when assessing response based on BCR-ABL1 cutoff limits. The last few years have witnessed the emergence of a new molecular response target, which is the achievement and maintenance of a deep molecular response. The ability to achieve treatment-free remission for some patients has shifted the relevant boundary for molecular response. However, the definitive safe BCR-ABL1 transcript level and length of the maintenance phase after which treatment cessation can be attempted has not yet been determined. For patients with TKI resistance, BCR-ABL1 kinase domain mutation analysis remains an essential assessment to guide therapy. Furthermore, low-level mutation detection is clinically relevant for response prediction to subsequent TKI therapy for some patients. Multiple low-level mutations may be a biomarker of a clonally diverse disease with the propensity for resistance evolution. Overall, molecular monitoring, including low-level monitoring is a fundamental component of management for patients with CML." @default.
• W2559066614 created "2016-12-08" @default.
• W2559066614 creator A5011454613 @default.
• W2559066614 date "2016-12-02" @default.
• W2559066614 modified "2023-09-30" @default.
• W2559066614 title "Molecular monitoring in chronic myeloid leukemia—how low can you go?" @default.
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• W2559066614 doi "https://doi.org/10.1182/asheducation-2016.1.156" @default.
• W2559066614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6142476" @default.
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