FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2559080324> ?p ?o ?g. }

• W2559080324 abstract "Background: Oxidative stress has been closely linked to the incidence of diabetic complications. Therefore, the aim of this research article was to study hyperglycemia and abnormal lipid profile in diabetic patient type 2 and its correlation with oxidative stress development as measured by 8-iso-PGF2α and 8-OHdG. Methods: Fifty (50) patients confirmed type 2 diabetes mellitus and eighty (80) non-diabetic control individuals were included in this study. All individuals were tested for blood glucose, lipid profile, 8-iso-PGF2α and 8-OHdG HdG. Results: The age of diabetic patients was observed to be ≥40 yrs in 96% and diabetes was frequently detected in female than in male patients (76% vs. 24%, p < 0.0001). Mean serum lipids were elevated in diabetic patients compared with control individuals (p < 0.0001) except in HDL-C, a significant decrease was recorded (p = 0.04). Serum 8-iso-PGF2α and 8-OHdG were elevated significantly in diabetic patients compared with non-diabetic control and a significant correlation was recorded between them (r = 0.6, p < 0.0001). 8-iso-PGF2α was associated with Age (r = 0.394, p < 0.0001), FBG (0.553, p < 0.0001), LDL-C (r = 0.2, p = 0.023), TG (r = 0.176, p = 0.045) and TC (r = 0.2, p = 0.02). Also, 8-OHdG was associated with age (r = 0.558, p < 0.0001), FBG (r = 0.67, p < 0.0001), LDL-C (r = 0.28, p = 0.001), TG (r = 0.358, p < 0.0001) and TC (r = 0.33, p < 0.0001). Age, FBG, HbA1c, LDL-C, TG and TC showed a significant linear regression with 8-iso-PGF2α and 8-OHdG recording its role as significant predictors for the elevation of 8-iso-PGF2α and 8-OHdG. Therefore, hyperglycemia with oxidative stress development may play a role for dyslipidemia and diabetic complications. Conclusion: Diabetic patient’s type 2 has a higher rate of abnormal serum lipids and correlates significantly with lipid peroxidation and oxidized DNA bases as measured by 8-iso-PGF2α and 8-OHdG. Therefore, 8-iso-PGF2α and 8-OHdG could be used as oxidative biomarkers for evaluating diabetic patients with early prediction of its complications and cancer development." @default.
• W2559080324 created "2016-12-08" @default.
• W2559080324 creator A5009600366 @default.
• W2559080324 creator A5019048069 @default.
• W2559080324 creator A5028057428 @default.
• W2559080324 creator A5068489489 @default.
• W2559080324 date "2016-01-01" @default.
• W2559080324 modified "2023-10-01" @default.
• W2559080324 title "The Activity of Serum 8-Iso-Prostaglandin F2<i>α</i> as Oxidative Stress Marker in Patients with Diabetes Mellitus Type 2 and Associated Dyslipidemic Hyperglycemia" @default.
• W2559080324 cites W1559537922 @default.
• W2559080324 cites W1752045965 @default.
• W2559080324 cites W1794856894 @default.
• W2559080324 cites W1968914335 @default.
• W2559080324 cites W1972405786 @default.
• W2559080324 cites W1975964004 @default.
• W2559080324 cites W1981870124 @default.
• W2559080324 cites W1989844152 @default.
• W2559080324 cites W1998566081 @default.
• W2559080324 cites W2011727323 @default.
• W2559080324 cites W2016514524 @default.
• W2559080324 cites W2019369653 @default.
• W2559080324 cites W2020383780 @default.
• W2559080324 cites W2020659754 @default.
• W2559080324 cites W2028927832 @default.
• W2559080324 cites W2035069368 @default.
• W2559080324 cites W2043009133 @default.
• W2559080324 cites W2043836955 @default.
• W2559080324 cites W2044437167 @default.
• W2559080324 cites W2051175928 @default.
• W2559080324 cites W2058769538 @default.
• W2559080324 cites W2059403223 @default.
• W2559080324 cites W2069652505 @default.
• W2559080324 cites W2071036089 @default.
• W2559080324 cites W2076018821 @default.
• W2559080324 cites W2080987644 @default.
• W2559080324 cites W2082561823 @default.
• W2559080324 cites W2093584578 @default.
• W2559080324 cites W2093894290 @default.
• W2559080324 cites W2094865265 @default.
• W2559080324 cites W2102719206 @default.
• W2559080324 cites W2105362864 @default.
• W2559080324 cites W2109977819 @default.
• W2559080324 cites W2115766950 @default.
• W2559080324 cites W2116404316 @default.
• W2559080324 cites W2117462751 @default.
• W2559080324 cites W2127307547 @default.
• W2559080324 cites W2133478305 @default.
• W2559080324 cites W2138443291 @default.
• W2559080324 cites W2139107938 @default.
• W2559080324 cites W2141561164 @default.
• W2559080324 cites W2149021962 @default.
• W2559080324 cites W2157495535 @default.
• W2559080324 cites W2266256585 @default.
• W2559080324 cites W2345903479 @default.
• W2559080324 cites W2520432709 @default.
• W2559080324 cites W2186397669 @default.
• W2559080324 cites W2337109902 @default.
• W2559080324 doi "https://doi.org/10.4236/jdm.2016.64033" @default.
• W2559080324 hasPublicationYear "2016" @default.
• W2559080324 type Work @default.
• W2559080324 sameAs 2559080324 @default.
• W2559080324 citedByCount "4" @default.
• W2559080324 countsByYear W25590803242019 @default.
• W2559080324 countsByYear W25590803242021 @default.
• W2559080324 countsByYear W25590803242022 @default.
• W2559080324 crossrefType "journal-article" @default.
• W2559080324 hasAuthorship W2559080324A5009600366 @default.
• W2559080324 hasAuthorship W2559080324A5019048069 @default.
• W2559080324 hasAuthorship W2559080324A5028057428 @default.
• W2559080324 hasAuthorship W2559080324A5068489489 @default.
• W2559080324 hasBestOaLocation W25590803241 @default.
• W2559080324 hasConcept C120665830 @default.
• W2559080324 hasConcept C121332964 @default.
• W2559080324 hasConcept C126322002 @default.
• W2559080324 hasConcept C134018914 @default.
• W2559080324 hasConcept C2776151105 @default.
• W2559080324 hasConcept C2777180221 @default.
• W2559080324 hasConcept C2778270857 @default.
• W2559080324 hasConcept C2910068830 @default.
• W2559080324 hasConcept C555293320 @default.
• W2559080324 hasConcept C61511704 @default.
• W2559080324 hasConcept C71924100 @default.
• W2559080324 hasConcept C90924648 @default.
• W2559080324 hasConceptScore W2559080324C120665830 @default.
• W2559080324 hasConceptScore W2559080324C121332964 @default.
• W2559080324 hasConceptScore W2559080324C126322002 @default.
• W2559080324 hasConceptScore W2559080324C134018914 @default.
• W2559080324 hasConceptScore W2559080324C2776151105 @default.
• W2559080324 hasConceptScore W2559080324C2777180221 @default.
• W2559080324 hasConceptScore W2559080324C2778270857 @default.
• W2559080324 hasConceptScore W2559080324C2910068830 @default.
• W2559080324 hasConceptScore W2559080324C555293320 @default.
• W2559080324 hasConceptScore W2559080324C61511704 @default.
• W2559080324 hasConceptScore W2559080324C71924100 @default.
• W2559080324 hasConceptScore W2559080324C90924648 @default.
• W2559080324 hasLocation W25590803241 @default.
• W2559080324 hasOpenAccess W2559080324 @default.
• W2559080324 hasPrimaryLocation W25590803241 @default.
• W2559080324 hasRelatedWork W1984618853 @default.
• W2559080324 hasRelatedWork W2037069230 @default.

• next