Matches in SemOpenAlex for { <https://semopenalex.org/work/W2559090923> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- W2559090923 endingPage "119" @default.
- W2559090923 startingPage "119" @default.
- W2559090923 abstract "This case report highlights the role of hyperglycaemia in a dissociative syndrome that may be overlooked by physicians, until it results in significant consequences. Traditionally dissociation is considered as an escape from overwhelming distress with partial or complete loss of control on voluntary actions or alienation of oneself or external world [6]. Possible biological factors implicated in pathogenesis include reduced perfusion in inferior prefrontal and anterior temporal regions in the right hemisphere and abnormal functioning of the Hypothalamo-Pituitary-Adrenal dysfunction, Glutamate/N-Methyl-D-Aspartate (NMDA) receptor, Serotonin (5-HT2a, 5-HT2c), Gama-Amino Butyric Acid (GABA), and Opioid receptors[7, 8].Though diabetes may impair attention, speed of information processing, motor skills, working memory, the mechanism involved in the occurrence of dissociative fugue is unknown [9]. NMDA receptor that plays important role in cognitive impairment in other disorder (e.g. Alzheimer dementia) appears to play a role in causation of dissociative symptoms. Diabetes can induce NMDA receptor subunit composition resulting in cognitive impairment, and NMDA-receptor antagonists have shown to improves cognitive in over activation [10,11].On other hand activation of NMDA receptors in the dorsal vagal complex lowers glucose production, and it involved in glucose stimulated insulin secretion from beta cells [12]. Role of GABA and 5HT2 is unclear. The activation of GABA (A) receptors decreased insulin secretion and GABA (B) receptor antagonist increase insulin release in islets type 2 diabetic[13] .GABA synthesis is impaired in hyperglycaemic state [14,7].GABA-A antagonism and 5-HT2a/2c agonism can induce dissociative-like symptoms [15]. 5-HT2A receptors are implicated in the molecular mechanisms of anti-diabetic medication16.Hyper activation of the HPA axis is also reported in diabetes [5].Thus in isolation or in combination of above pathophysiology, hyperglycaemic state may result in dissociative symptoms." @default.
- W2559090923 created "2016-12-08" @default.
- W2559090923 creator A5016001737 @default.
- W2559090923 creator A5078920238 @default.
- W2559090923 creator A5079515988 @default.
- W2559090923 date "2016-01-01" @default.
- W2559090923 modified "2023-09-25" @default.
- W2559090923 title "Hyperglycaemic Dissociative Fugue in an Elderly- A Rare Case Report" @default.
- W2559090923 doi "https://doi.org/10.5455/jnbs.1436763747" @default.
- W2559090923 hasPublicationYear "2016" @default.
- W2559090923 type Work @default.
- W2559090923 sameAs 2559090923 @default.
- W2559090923 citedByCount "0" @default.
- W2559090923 crossrefType "journal-article" @default.
- W2559090923 hasAuthorship W2559090923A5016001737 @default.
- W2559090923 hasAuthorship W2559090923A5078920238 @default.
- W2559090923 hasAuthorship W2559090923A5079515988 @default.
- W2559090923 hasConcept C124952713 @default.
- W2559090923 hasConcept C142362112 @default.
- W2559090923 hasConcept C15744967 @default.
- W2559090923 hasConcept C2775859031 @default.
- W2559090923 hasConcept C71924100 @default.
- W2559090923 hasConceptScore W2559090923C124952713 @default.
- W2559090923 hasConceptScore W2559090923C142362112 @default.
- W2559090923 hasConceptScore W2559090923C15744967 @default.
- W2559090923 hasConceptScore W2559090923C2775859031 @default.
- W2559090923 hasConceptScore W2559090923C71924100 @default.
- W2559090923 hasIssue "3" @default.
- W2559090923 hasLocation W25590909231 @default.
- W2559090923 hasOpenAccess W2559090923 @default.
- W2559090923 hasPrimaryLocation W25590909231 @default.
- W2559090923 hasRelatedWork W1506200166 @default.
- W2559090923 hasRelatedWork W1995515455 @default.
- W2559090923 hasRelatedWork W2039318446 @default.
- W2559090923 hasRelatedWork W2048182022 @default.
- W2559090923 hasRelatedWork W2080531066 @default.
- W2559090923 hasRelatedWork W2604872355 @default.
- W2559090923 hasRelatedWork W2748952813 @default.
- W2559090923 hasRelatedWork W2899084033 @default.
- W2559090923 hasRelatedWork W3032375762 @default.
- W2559090923 hasRelatedWork W3108674512 @default.
- W2559090923 hasVolume "3" @default.
- W2559090923 isParatext "false" @default.
- W2559090923 isRetracted "false" @default.
- W2559090923 magId "2559090923" @default.
- W2559090923 workType "article" @default.