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- W2559251588 endingPage "473" @default.
- W2559251588 startingPage "455" @default.
- W2559251588 abstract "In skeletal muscles, levels and activity of Matrix MetalloProteinases (MMPs) and Tissue Inhibitors of MetalloProteinases (TIMPs) have been involved in myoblast migration, fusion and various physiological and pathological remodeling situations including neuromuscular diseases. This has opened perspectives for the use of MMPs' overexpression to improve the efficiency of cell therapy in muscular dystrophies and resolve fibrosis. Alternatively, inhibition of individual MMPs in animal models of muscular dystrophies has provided evidence of beneficial, dual or adverse effects on muscle morphology or function. We review here the role played by MMPs/TIMPs in skeletal muscle inflammation and fibrosis, two major hurdles that limit the success of cell and gene therapy. We report and analyze the consequences of genetic or pharmacological modulation of MMP levels on the inflammation of skeletal muscles and their repair in light of experimental findings. We further discuss how the interplay between MMPs/TIMPs levels, cytokines/chemokines, growth factors and permanent low-grade inflammation favor cellular and molecular modifications resulting in fibrosis." @default.
- W2559251588 created "2016-12-08" @default.
- W2559251588 creator A5046261021 @default.
- W2559251588 creator A5083488847 @default.
- W2559251588 date "2016-11-29" @default.
- W2559251588 modified "2023-10-14" @default.
- W2559251588 title "Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Inflammation and Fibrosis of Skeletal Muscles" @default.
- W2559251588 cites W104507882 @default.
- W2559251588 cites W1259600258 @default.
- W2559251588 cites W1481220364 @default.
- W2559251588 cites W1482504262 @default.
- W2559251588 cites W1504021012 @default.
- W2559251588 cites W1505978562 @default.
- W2559251588 cites W1514670900 @default.
- W2559251588 cites W1522403604 @default.
- W2559251588 cites W1562667342 @default.
- W2559251588 cites W1572327103 @default.
- W2559251588 cites W1576104036 @default.
- W2559251588 cites W1588127651 @default.
- W2559251588 cites W1588947274 @default.
- W2559251588 cites W1599728739 @default.
- W2559251588 cites W1607220690 @default.
- W2559251588 cites W1633780551 @default.
- W2559251588 cites W1730313527 @default.
- W2559251588 cites W1823253650 @default.
- W2559251588 cites W1878807841 @default.
- W2559251588 cites W1896931259 @default.
- W2559251588 cites W1935086422 @default.
- W2559251588 cites W1949259756 @default.
- W2559251588 cites W1965761285 @default.
- W2559251588 cites W1968854849 @default.
- W2559251588 cites W19695552 @default.
- W2559251588 cites W1970422084 @default.
- W2559251588 cites W1971055416 @default.
- W2559251588 cites W1971244052 @default.
- W2559251588 cites W1971711041 @default.
- W2559251588 cites W1973895231 @default.
- W2559251588 cites W1974595871 @default.
- W2559251588 cites W1975907236 @default.
- W2559251588 cites W1977197329 @default.
- W2559251588 cites W1977910585 @default.
- W2559251588 cites W1977980068 @default.
- W2559251588 cites W1978164136 @default.
- W2559251588 cites W1979926151 @default.
- W2559251588 cites W1980325398 @default.
- W2559251588 cites W1980606567 @default.
- W2559251588 cites W1984483611 @default.
- W2559251588 cites W1986480779 @default.
- W2559251588 cites W1986736465 @default.
- W2559251588 cites W1988449987 @default.
- W2559251588 cites W1989630978 @default.
- W2559251588 cites W1990103645 @default.
- W2559251588 cites W1990877246 @default.
- W2559251588 cites W1992169401 @default.
- W2559251588 cites W1992399334 @default.
- W2559251588 cites W1992866169 @default.
- W2559251588 cites W1993330421 @default.
- W2559251588 cites W1993551589 @default.
- W2559251588 cites W1994787439 @default.
- W2559251588 cites W1995011038 @default.
- W2559251588 cites W1995457093 @default.
- W2559251588 cites W1995528629 @default.
- W2559251588 cites W1997639385 @default.
- W2559251588 cites W1999227691 @default.
- W2559251588 cites W1999351569 @default.
- W2559251588 cites W2002771508 @default.
- W2559251588 cites W2003500892 @default.
- W2559251588 cites W2003649729 @default.
- W2559251588 cites W2005926287 @default.
- W2559251588 cites W2006311087 @default.
- W2559251588 cites W2009769042 @default.
- W2559251588 cites W2015100707 @default.
- W2559251588 cites W2016101910 @default.
- W2559251588 cites W2016205146 @default.
- W2559251588 cites W2016484384 @default.
- W2559251588 cites W2017504550 @default.
- W2559251588 cites W2019631420 @default.
- W2559251588 cites W2019921405 @default.
- W2559251588 cites W2020119808 @default.
- W2559251588 cites W2021356484 @default.
- W2559251588 cites W2022043455 @default.
- W2559251588 cites W2022078198 @default.
- W2559251588 cites W2022655531 @default.
- W2559251588 cites W2025922826 @default.
- W2559251588 cites W2026158623 @default.
- W2559251588 cites W2029782642 @default.
- W2559251588 cites W2031153860 @default.
- W2559251588 cites W2031459560 @default.
- W2559251588 cites W2033653350 @default.
- W2559251588 cites W2034184306 @default.
- W2559251588 cites W2035841380 @default.
- W2559251588 cites W2035991981 @default.
- W2559251588 cites W2036322339 @default.
- W2559251588 cites W2036655914 @default.
- W2559251588 cites W2037150895 @default.
- W2559251588 cites W2037548154 @default.
- W2559251588 cites W2037786647 @default.
- W2559251588 cites W2039809246 @default.