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- W2559349577 abstract "The paucity of FDA approved adjuvants renders the synthesis, characterization, and use of new compounds as vaccine adjuvants, a necessity. For this purpose, a novel saccharide analog has been synthesized from glucosamine, pyruvylated galactose and 1,4-cyclohexanediol and its biological efficacy was determined in innate immune cells. More specifically, we assessed the production of pro-inflammatory cytokines from the murine monocyte cell line, Raw 264.7 and from C57 BL/6 mouse peritoneal macrophages following exposure to the saccharide analog. Our data conclude that the novel saccharide has immunostimulatory activity on mouse macrophages as indicated by the elevated levels of IL-6 and TNF-α in culture supernatants. This effect was TLR-4-dependent but TLR-2-independent. Our data, suggest TLR-4 agonism; a key feature of vaccine adjuvants." @default.
- W2559349577 created "2016-12-08" @default.
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- W2559349577 date "2017-01-01" @default.
- W2559349577 modified "2023-09-29" @default.
- W2559349577 title "Synthesis and immunological evaluation of a low molecular weight saccharide with TLR-4 agonist activity" @default.
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- W2559349577 doi "https://doi.org/10.1016/j.bmc.2016.11.044" @default.
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