Matches in SemOpenAlex for { <https://semopenalex.org/work/W2559362783> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2559362783 endingPage "1125" @default.
- W2559362783 startingPage "1119" @default.
- W2559362783 abstract "Ling-Gui-Zhu-Gan Decoction (LGZGD) formula, derived from traditional Chinese medicine (TCM), has definitive clinical efficacy in the treatment of heart failure (HF) in China. However, little is known of the underlying mechanism of LGZGD.The aim of this work was to investigate the therapeutic mechanism of LGZGD on HF treatment based on an integration of the serum metabolomics and network analysis.HF model mice were established by intraperitoneal injecting of doxorubicin. Body weight, echocardiography, biochemical assay and hematoxylin and eosin staining experiments were used to evaluate the efficacy of LGZGD. A metabolomics approach based on ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) was performed to analyze the serum biomarkers from model group, control group and LGZGD-treatment group. Principle component analysis (PCA) and orthogonal projection to latent structures-discriminant analysis (OPLS-DA) were utilized to identify differences of metabolic profiles in mice among the three groups. The network of “gene-enzyme-metabolite” was built to investigate the possible mechanism of LGZGD from the systematic perspective.54 metabolites, which showed a significantly restoring trend from HF to normal condition, were regarded as potential biomarkers of LGZGD treatment. The most critical pathway was glycerophospholipid metabolism and arachidonic acid metabolism. According to the results of network analysis, 8 biomarkers were regarded as hub metabolites, which meant these metabolites may have a major relationship with the LGZGD therapeutic effects for the HF. 8 enzymes and 29 genes in the network were considered as potential targets of LGZGD treatment.By integrated serum metabolomic and network analysis, we found that LGZGD might retard the pathological process of HF by regulating the disturbed metabolic pathways and the relative enzymes, which may be potential mechanism for LGZGD in the treatment of HF." @default.
- W2559362783 created "2016-12-08" @default.
- W2559362783 creator A5049253920 @default.
- W2559362783 date "2016-12-01" @default.
- W2559362783 modified "2023-10-02" @default.
- W2559362783 title "Comentarios a la guía ESC 2016 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica" @default.
- W2559362783 cites W2018525532 @default.
- W2559362783 cites W2106834261 @default.
- W2559362783 cites W2111957989 @default.
- W2559362783 cites W2113698123 @default.
- W2559362783 cites W2135795923 @default.
- W2559362783 cites W2143706308 @default.
- W2559362783 cites W2146264128 @default.
- W2559362783 cites W2154650976 @default.
- W2559362783 cites W2162863343 @default.
- W2559362783 cites W2178738676 @default.
- W2559362783 cites W2224893286 @default.
- W2559362783 cites W2334631623 @default.
- W2559362783 cites W2342218305 @default.
- W2559362783 cites W2380447421 @default.
- W2559362783 cites W2425644022 @default.
- W2559362783 cites W2427094903 @default.
- W2559362783 cites W2518530324 @default.
- W2559362783 doi "https://doi.org/10.1016/j.recesp.2016.09.056" @default.
- W2559362783 hasPublicationYear "2016" @default.
- W2559362783 type Work @default.
- W2559362783 sameAs 2559362783 @default.
- W2559362783 citedByCount "19" @default.
- W2559362783 countsByYear W25593627832017 @default.
- W2559362783 countsByYear W25593627832018 @default.
- W2559362783 countsByYear W25593627832019 @default.
- W2559362783 countsByYear W25593627832021 @default.
- W2559362783 countsByYear W25593627832023 @default.
- W2559362783 crossrefType "journal-article" @default.
- W2559362783 hasAuthorship W2559362783A5049253920 @default.
- W2559362783 hasConcept C126322002 @default.
- W2559362783 hasConcept C142724271 @default.
- W2559362783 hasConcept C181199279 @default.
- W2559362783 hasConcept C185592680 @default.
- W2559362783 hasConcept C188947578 @default.
- W2559362783 hasConcept C190409667 @default.
- W2559362783 hasConcept C204787440 @default.
- W2559362783 hasConcept C21565614 @default.
- W2559362783 hasConcept C2776952329 @default.
- W2559362783 hasConcept C2777477808 @default.
- W2559362783 hasConcept C2778078955 @default.
- W2559362783 hasConcept C2778198053 @default.
- W2559362783 hasConcept C2778918659 @default.
- W2559362783 hasConcept C41625074 @default.
- W2559362783 hasConcept C55493867 @default.
- W2559362783 hasConcept C60644358 @default.
- W2559362783 hasConcept C71924100 @default.
- W2559362783 hasConcept C86803240 @default.
- W2559362783 hasConcept C98274493 @default.
- W2559362783 hasConceptScore W2559362783C126322002 @default.
- W2559362783 hasConceptScore W2559362783C142724271 @default.
- W2559362783 hasConceptScore W2559362783C181199279 @default.
- W2559362783 hasConceptScore W2559362783C185592680 @default.
- W2559362783 hasConceptScore W2559362783C188947578 @default.
- W2559362783 hasConceptScore W2559362783C190409667 @default.
- W2559362783 hasConceptScore W2559362783C204787440 @default.
- W2559362783 hasConceptScore W2559362783C21565614 @default.
- W2559362783 hasConceptScore W2559362783C2776952329 @default.
- W2559362783 hasConceptScore W2559362783C2777477808 @default.
- W2559362783 hasConceptScore W2559362783C2778078955 @default.
- W2559362783 hasConceptScore W2559362783C2778198053 @default.
- W2559362783 hasConceptScore W2559362783C2778918659 @default.
- W2559362783 hasConceptScore W2559362783C41625074 @default.
- W2559362783 hasConceptScore W2559362783C55493867 @default.
- W2559362783 hasConceptScore W2559362783C60644358 @default.
- W2559362783 hasConceptScore W2559362783C71924100 @default.
- W2559362783 hasConceptScore W2559362783C86803240 @default.
- W2559362783 hasConceptScore W2559362783C98274493 @default.
- W2559362783 hasIssue "12" @default.
- W2559362783 hasLocation W25593627831 @default.
- W2559362783 hasOpenAccess W2559362783 @default.
- W2559362783 hasPrimaryLocation W25593627831 @default.
- W2559362783 hasRelatedWork W2030065489 @default.
- W2559362783 hasRelatedWork W2066723852 @default.
- W2559362783 hasRelatedWork W2349520533 @default.
- W2559362783 hasRelatedWork W2364315362 @default.
- W2559362783 hasRelatedWork W2376405497 @default.
- W2559362783 hasRelatedWork W2752979852 @default.
- W2559362783 hasRelatedWork W2913921801 @default.
- W2559362783 hasRelatedWork W2992382265 @default.
- W2559362783 hasRelatedWork W3030644755 @default.
- W2559362783 hasRelatedWork W4311821919 @default.
- W2559362783 hasVolume "69" @default.
- W2559362783 isParatext "false" @default.
- W2559362783 isRetracted "false" @default.
- W2559362783 magId "2559362783" @default.
- W2559362783 workType "article" @default.