Matches in SemOpenAlex for { <https://semopenalex.org/work/W2559431510> ?p ?o ?g. }
- W2559431510 endingPage "378" @default.
- W2559431510 startingPage "366" @default.
- W2559431510 abstract "Although rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is the standard treatment for patients with diffuse large B-cell lymphoma (DLBCL), ∼30% to 50% of patients are not cured by this treatment, depending on disease stage or prognostic index. Among patients for whom R-CHOP therapy fails, 20% suffer from primary refractory disease (progress during or right after treatment) whereas 30% relapse after achieving complete remission (CR). Currently, there is no good definition enabling us to identify these 2 groups upon diagnosis. Most of the refractory patients exhibit double-hit lymphoma (MYC-BCL2 rearrangement) or double-protein-expression lymphoma (MYC-BCL2 hyperexpression) which have a more aggressive clinical picture. New strategies are currently being explored to obtain better CR rates and fewer relapses. Although young relapsing patients are treated with high-dose therapy followed by autologous transplant, there is an unmet need for better salvage regimens in this setting. To prevent relapse, maintenance therapy with immunomodulatory agents such as lenalidomide is currently undergoing investigation. New drugs will most likely be introduced over the next few years and will probably be different for relapsing and refractory patients." @default.
- W2559431510 created "2016-12-08" @default.
- W2559431510 creator A5003105021 @default.
- W2559431510 creator A5044269394 @default.
- W2559431510 date "2016-12-02" @default.
- W2559431510 modified "2023-10-16" @default.
- W2559431510 title "Diffuse large B-cell lymphoma: R-CHOP failure—what to do?" @default.
- W2559431510 cites W1020989877 @default.
- W2559431510 cites W1038865554 @default.
- W2559431510 cites W1203878641 @default.
- W2559431510 cites W1209888207 @default.
- W2559431510 cites W1456239636 @default.
- W2559431510 cites W1493375167 @default.
- W2559431510 cites W1501101670 @default.
- W2559431510 cites W1529496601 @default.
- W2559431510 cites W1549911120 @default.
- W2559431510 cites W1567594688 @default.
- W2559431510 cites W1608768034 @default.
- W2559431510 cites W1628369270 @default.
- W2559431510 cites W1797732564 @default.
- W2559431510 cites W1811309007 @default.
- W2559431510 cites W1857674108 @default.
- W2559431510 cites W1870781852 @default.
- W2559431510 cites W1909399984 @default.
- W2559431510 cites W1922147868 @default.
- W2559431510 cites W1933805596 @default.
- W2559431510 cites W1934992232 @default.
- W2559431510 cites W1949194036 @default.
- W2559431510 cites W1949227380 @default.
- W2559431510 cites W1966062502 @default.
- W2559431510 cites W1971503837 @default.
- W2559431510 cites W1972426790 @default.
- W2559431510 cites W1972550125 @default.
- W2559431510 cites W1972901472 @default.
- W2559431510 cites W1974521585 @default.
- W2559431510 cites W1976510049 @default.
- W2559431510 cites W1978442810 @default.
- W2559431510 cites W1983963101 @default.
- W2559431510 cites W1985016870 @default.
- W2559431510 cites W1986329161 @default.
- W2559431510 cites W1988817337 @default.
- W2559431510 cites W1989963052 @default.
- W2559431510 cites W1992234322 @default.
- W2559431510 cites W1996473695 @default.
- W2559431510 cites W1996671618 @default.
- W2559431510 cites W2003874772 @default.
- W2559431510 cites W2006070956 @default.
- W2559431510 cites W2013598192 @default.
- W2559431510 cites W2018071905 @default.
- W2559431510 cites W2018368873 @default.
- W2559431510 cites W2022852318 @default.
- W2559431510 cites W2024972915 @default.
- W2559431510 cites W2027633034 @default.
- W2559431510 cites W2028850684 @default.
- W2559431510 cites W2029421916 @default.
- W2559431510 cites W2032390966 @default.
- W2559431510 cites W2040113238 @default.
- W2559431510 cites W2044154548 @default.
- W2559431510 cites W2044947137 @default.
- W2559431510 cites W2048389563 @default.
- W2559431510 cites W2050100708 @default.
- W2559431510 cites W2050783850 @default.
- W2559431510 cites W2051058786 @default.
- W2559431510 cites W2052287188 @default.
- W2559431510 cites W2052460421 @default.
- W2559431510 cites W2054274023 @default.
- W2559431510 cites W2056641238 @default.
- W2559431510 cites W2056677678 @default.
- W2559431510 cites W2058574523 @default.
- W2559431510 cites W2059435013 @default.
- W2559431510 cites W2060466778 @default.
- W2559431510 cites W2061316813 @default.
- W2559431510 cites W2067860443 @default.
- W2559431510 cites W2071280552 @default.
- W2559431510 cites W2071817259 @default.
- W2559431510 cites W2073119951 @default.
- W2559431510 cites W2073125824 @default.
- W2559431510 cites W2077320602 @default.
- W2559431510 cites W2083490815 @default.
- W2559431510 cites W2091948511 @default.
- W2559431510 cites W2093121143 @default.
- W2559431510 cites W2096301685 @default.
- W2559431510 cites W2096596684 @default.
- W2559431510 cites W2097145287 @default.
- W2559431510 cites W2097561270 @default.
- W2559431510 cites W2097870229 @default.
- W2559431510 cites W2101487191 @default.
- W2559431510 cites W2103382997 @default.
- W2559431510 cites W2108928912 @default.
- W2559431510 cites W2109270307 @default.
- W2559431510 cites W2113950318 @default.
- W2559431510 cites W2119050380 @default.
- W2559431510 cites W2120415962 @default.
- W2559431510 cites W2120572492 @default.
- W2559431510 cites W2123160735 @default.
- W2559431510 cites W2126779872 @default.
- W2559431510 cites W2127501655 @default.
- W2559431510 cites W2129272684 @default.