FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2559590913> ?p ?o ?g. }

• W2559590913 endingPage "e0166770" @default.
• W2559590913 startingPage "e0166770" @default.
• W2559590913 abstract "Burn injury is associated with a loss of gut barrier function, resulting in systemic dissemination of gut-derived bacteria and their products. The bacterial protein and TLR5 agonist, flagellin, induces non-specific innate immune responses. Because we detected flagellin in the serum of burn patients, we investigated whether gut-derived flagellin was a primary or secondary contributor to intestinal dysfunction and systemic inflammation following burn injury. The apical surface of polarized human intestinal epithelial cells (IECs), Caco-2BBe, were exposed to 50 or 500 ng of purified flagellin and 1 x 105 of an intestinal E. coli (EC) isolate as follows: 1) flagellin added 30 min prior to EC, 2) flagellin and EC added simultaneously, or 3) EC added 30 min prior to flagellin. Our results showed that luminal flagellin and EC modulated each other's biological actions, which influenced their ability to induce basolateral secretion of inflammatory cytokines and subsequent translocation of bacteria and their products. A low dose of flagellin accompanied by an enteric EC in the lumen, tempered inflammation in a dose- and time-dependent manner. However, higher doses of flagellin acted synergistically with EC to induce both intestinal and systemic inflammation that compromised barrier integrity, increasing systemic inflammation following burn injury, a process we have termed flagellemia. In a murine model of burn injury we found that oral gavage of flagellin (1 μg/mouse) significantly affected the gut microbiome after burn injury. In these mice, flagellin disseminated out of the intestine into the serum and to distal organs (mesenteric lymph nodes and lungs) where it induced secretion of monocyte chemoattractant protein (MCP-1) and CXCL1/KC (mouse equivalent of human IL-8) at 24 and 48h post-burn. Our results illustrated that gut-derived flagellin alone or accompanied by a non-pathogenic enteric EC strain can function as an initiator of luminal and systemic inflammation following burn injury." @default.
• W2559590913 created "2016-12-08" @default.
• W2559590913 creator A5001389761 @default.
• W2559590913 creator A5002646356 @default.
• W2559590913 creator A5020448366 @default.
• W2559590913 creator A5043159235 @default.
• W2559590913 creator A5047757248 @default.
• W2559590913 creator A5058049602 @default.
• W2559590913 creator A5061796753 @default.
• W2559590913 creator A5077662103 @default.
• W2559590913 date "2016-12-01" @default.
• W2559590913 modified "2023-10-18" @default.
• W2559590913 title "Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury" @default.
• W2559590913 cites W1488560084 @default.
• W2559590913 cites W1508362664 @default.
• W2559590913 cites W1513304325 @default.
• W2559590913 cites W1519633296 @default.
• W2559590913 cites W1548446792 @default.
• W2559590913 cites W1552658552 @default.
• W2559590913 cites W1940453590 @default.
• W2559590913 cites W1945289679 @default.
• W2559590913 cites W1974246309 @default.
• W2559590913 cites W1978465433 @default.
• W2559590913 cites W1984345127 @default.
• W2559590913 cites W1985508783 @default.
• W2559590913 cites W1986682458 @default.
• W2559590913 cites W1989432109 @default.
• W2559590913 cites W1992196525 @default.
• W2559590913 cites W1992485642 @default.
• W2559590913 cites W1993865500 @default.
• W2559590913 cites W2005800860 @default.
• W2559590913 cites W2013067182 @default.
• W2559590913 cites W2013608085 @default.
• W2559590913 cites W2015466060 @default.
• W2559590913 cites W2017116274 @default.
• W2559590913 cites W2017237401 @default.
• W2559590913 cites W2028600297 @default.
• W2559590913 cites W2028969161 @default.
• W2559590913 cites W2031805480 @default.
• W2559590913 cites W2035619664 @default.
• W2559590913 cites W2048830729 @default.
• W2559590913 cites W2049927679 @default.
• W2559590913 cites W2052230840 @default.
• W2559590913 cites W2056585868 @default.
• W2559590913 cites W2057477429 @default.
• W2559590913 cites W2057809738 @default.
• W2559590913 cites W2059575707 @default.
• W2559590913 cites W2076213629 @default.
• W2559590913 cites W2083089709 @default.
• W2559590913 cites W2097701668 @default.
• W2559590913 cites W2101323935 @default.
• W2559590913 cites W2103015797 @default.
• W2559590913 cites W2104472257 @default.
• W2559590913 cites W2109290583 @default.
• W2559590913 cites W2109594310 @default.
• W2559590913 cites W2119433822 @default.
• W2559590913 cites W2120180947 @default.
• W2559590913 cites W2122459017 @default.
• W2559590913 cites W2125309974 @default.
• W2559590913 cites W2134665695 @default.
• W2559590913 cites W2138007859 @default.
• W2559590913 cites W2153037170 @default.
• W2559590913 cites W2155503625 @default.
• W2559590913 cites W2164240196 @default.
• W2559590913 cites W2171323358 @default.
• W2559590913 cites W46876298 @default.
• W2559590913 doi "https://doi.org/10.1371/journal.pone.0166770" @default.
• W2559590913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5245817" @default.
• W2559590913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28103320" @default.
• W2559590913 hasPublicationYear "2016" @default.
• W2559590913 type Work @default.
• W2559590913 sameAs 2559590913 @default.
• W2559590913 citedByCount "16" @default.
• W2559590913 countsByYear W25595909132017 @default.
• W2559590913 countsByYear W25595909132018 @default.
• W2559590913 countsByYear W25595909132019 @default.
• W2559590913 countsByYear W25595909132020 @default.
• W2559590913 countsByYear W25595909132021 @default.
• W2559590913 countsByYear W25595909132022 @default.
• W2559590913 countsByYear W25595909132023 @default.
• W2559590913 crossrefType "journal-article" @default.
• W2559590913 hasAuthorship W2559590913A5001389761 @default.
• W2559590913 hasAuthorship W2559590913A5002646356 @default.
• W2559590913 hasAuthorship W2559590913A5020448366 @default.
• W2559590913 hasAuthorship W2559590913A5043159235 @default.
• W2559590913 hasAuthorship W2559590913A5047757248 @default.
• W2559590913 hasAuthorship W2559590913A5058049602 @default.
• W2559590913 hasAuthorship W2559590913A5061796753 @default.
• W2559590913 hasAuthorship W2559590913A5077662103 @default.
• W2559590913 hasBestOaLocation W25595909131 @default.
• W2559590913 hasConcept C126322002 @default.
• W2559590913 hasConcept C136449434 @default.
• W2559590913 hasConcept C203014093 @default.
• W2559590913 hasConcept C2776252253 @default.
• W2559590913 hasConcept C2776709828 @default.
• W2559590913 hasConcept C2776914184 @default.
• W2559590913 hasConcept C2777165150 @default.
• W2559590913 hasConcept C2777338127 @default.

• next