FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2559594057> ?p ?o ?g. }

• W2559594057 endingPage "287" @default.
• W2559594057 startingPage "281" @default.
• W2559594057 abstract "Abstract Recently we succeeded in preventing aggregation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) using polyelectrolytes. In the present work, the range of the model proteins has been extended at the expense of lysozyme and alpha-lactalbumin that are noticeably differed by isoelectric points. Experiments were performed both at higher and lower pH values than pI. In all cases, highly charged polycation or polyanion were capable of aggregation suppression. Furthermore, GAPDH was protected efficiently by both polyanion and polycation in all selected conditions. Noteworthy, in many cases protein protection was achieved by similarly charged polyelectrolyte, and the higher level of protection by polycation was achieved at lower pH despite the weakening of the Coulomb attraction. According to molecular dynamics simulations, polycation bound only negatively charged sites and formed loops and tails around protein surface. The unbound fragments seem to determine the high solubility of the complex and hence, are favorable the protein aggregation protection. The reported results could be important as a platform for the development of artificial chaperones." @default.
• W2559594057 created "2016-12-08" @default.
• W2559594057 creator A5042236390 @default.
• W2559594057 creator A5076252294 @default.
• W2559594057 creator A5087275016 @default.
• W2559594057 creator A5091525815 @default.
• W2559594057 date "2017-01-01" @default.
• W2559594057 modified "2023-09-24" @default.
• W2559594057 title "Similarly charged polyelectrolyte can be the most efficient suppressor of the protein aggregation" @default.
• W2559594057 cites W1143963669 @default.
• W2559594057 cites W1503328074 @default.
• W2559594057 cites W1520196879 @default.
• W2559594057 cites W1588992473 @default.
• W2559594057 cites W1926513104 @default.
• W2559594057 cites W1970715889 @default.
• W2559594057 cites W1999641150 @default.
• W2559594057 cites W2004630111 @default.
• W2559594057 cites W2014118668 @default.
• W2559594057 cites W2016492428 @default.
• W2559594057 cites W2017927099 @default.
• W2559594057 cites W2018569753 @default.
• W2559594057 cites W2022950330 @default.
• W2559594057 cites W2029582401 @default.
• W2559594057 cites W2035672439 @default.
• W2559594057 cites W2040631210 @default.
• W2559594057 cites W2041666193 @default.
• W2559594057 cites W2051323334 @default.
• W2559594057 cites W2056934481 @default.
• W2559594057 cites W2062502197 @default.
• W2559594057 cites W2077361112 @default.
• W2559594057 cites W2081306620 @default.
• W2559594057 cites W2082547742 @default.
• W2559594057 cites W2082549153 @default.
• W2559594057 cites W2084424281 @default.
• W2559594057 cites W2089973419 @default.
• W2559594057 cites W2101689833 @default.
• W2559594057 cites W2106186590 @default.
• W2559594057 cites W2138816428 @default.
• W2559594057 cites W2148151472 @default.
• W2559594057 cites W2160544821 @default.
• W2559594057 cites W2163125083 @default.
• W2559594057 cites W2165565773 @default.
• W2559594057 cites W2312184864 @default.
• W2559594057 cites W2313591123 @default.
• W2559594057 cites W2321081577 @default.
• W2559594057 cites W2326548484 @default.
• W2559594057 doi "https://doi.org/10.1016/j.polymer.2016.11.073" @default.
• W2559594057 hasPublicationYear "2017" @default.
• W2559594057 type Work @default.
• W2559594057 sameAs 2559594057 @default.
• W2559594057 citedByCount "22" @default.
• W2559594057 countsByYear W25595940572017 @default.
• W2559594057 countsByYear W25595940572018 @default.
• W2559594057 countsByYear W25595940572019 @default.
• W2559594057 countsByYear W25595940572020 @default.
• W2559594057 countsByYear W25595940572021 @default.
• W2559594057 countsByYear W25595940572022 @default.
• W2559594057 countsByYear W25595940572023 @default.
• W2559594057 crossrefType "journal-article" @default.
• W2559594057 hasAuthorship W2559594057A5042236390 @default.
• W2559594057 hasAuthorship W2559594057A5076252294 @default.
• W2559594057 hasAuthorship W2559594057A5087275016 @default.
• W2559594057 hasAuthorship W2559594057A5091525815 @default.
• W2559594057 hasConcept C104317684 @default.
• W2559594057 hasConcept C12554922 @default.
• W2559594057 hasConcept C127413603 @default.
• W2559594057 hasConcept C153356533 @default.
• W2559594057 hasConcept C178790620 @default.
• W2559594057 hasConcept C179185449 @default.
• W2559594057 hasConcept C185592680 @default.
• W2559594057 hasConcept C192562407 @default.
• W2559594057 hasConcept C42360764 @default.
• W2559594057 hasConcept C521977710 @default.
• W2559594057 hasConcept C55493867 @default.
• W2559594057 hasConcept C86803240 @default.
• W2559594057 hasConceptScore W2559594057C104317684 @default.
• W2559594057 hasConceptScore W2559594057C12554922 @default.
• W2559594057 hasConceptScore W2559594057C127413603 @default.
• W2559594057 hasConceptScore W2559594057C153356533 @default.
• W2559594057 hasConceptScore W2559594057C178790620 @default.
• W2559594057 hasConceptScore W2559594057C179185449 @default.
• W2559594057 hasConceptScore W2559594057C185592680 @default.
• W2559594057 hasConceptScore W2559594057C192562407 @default.
• W2559594057 hasConceptScore W2559594057C42360764 @default.
• W2559594057 hasConceptScore W2559594057C521977710 @default.
• W2559594057 hasConceptScore W2559594057C55493867 @default.
• W2559594057 hasConceptScore W2559594057C86803240 @default.
• W2559594057 hasFunder F4320321079 @default.
• W2559594057 hasLocation W25595940571 @default.
• W2559594057 hasOpenAccess W2559594057 @default.
• W2559594057 hasPrimaryLocation W25595940571 @default.
• W2559594057 hasRelatedWork W1554213688 @default.
• W2559594057 hasRelatedWork W2020115439 @default.
• W2559594057 hasRelatedWork W2031664051 @default.
• W2559594057 hasRelatedWork W2059611432 @default.
• W2559594057 hasRelatedWork W2075743164 @default.
• W2559594057 hasRelatedWork W2279978949 @default.
• W2559594057 hasRelatedWork W2335356451 @default.

• next