Matches in SemOpenAlex for { <https://semopenalex.org/work/W2559664404> ?p ?o ?g. }
- W2559664404 endingPage "152" @default.
- W2559664404 startingPage "123" @default.
- W2559664404 abstract "Magnetic nanoparticles, in combination with applied magnetic fields, can non-invasively focus delivery of small-molecule drugs and human cells to specific regions of the anatomy. This emerging technology could solve one of the main challenges in therapy development: delivery of a high concentration of the therapeutic agent to the target organ or tissue whilst reducing systemic dosing and off-target side effects. Several challenges, however, must be met before this technology can be applied either effectively or safely in the clinic to augment therapies. Multiple nanoparticle features interact to influence the efficiency of magnet-targeted delivery, and so their design will have a large influence on the success of therapeutic targeting. Iron oxide core size and composition affect the type and strength of magnetism, and thus the amount of force that can be applied by an external magnetic field, while particle behaviour within biological systems can be affected by particle size and coating. Preclinical researchers have investigated the use of magnetic targeting-based therapies across a wide range of conditions, and positive results have been reported for both cell and drug delivery applications. Furthermore, magnetic resonance imaging (MRI) can non-invasively monitor the success of targeted delivery—providing high-resolution anatomical information on particle location in preclinical and clinical contexts. In this chapter, we provide a basic introduction to the physical principles behind magnetic targeting technology, relevant design features of nanoparticles and magnetic targeting devices, an overview of preclinical and clinical applications, and an introduction to imaging magnetic particles in vivo." @default.
- W2559664404 created "2016-12-08" @default.
- W2559664404 creator A5032238485 @default.
- W2559664404 creator A5050011891 @default.
- W2559664404 creator A5050444658 @default.
- W2559664404 creator A5056747437 @default.
- W2559664404 creator A5072837275 @default.
- W2559664404 date "2016-11-26" @default.
- W2559664404 modified "2023-09-23" @default.
- W2559664404 title "Magnet-Targeted Delivery and Imaging" @default.
- W2559664404 cites W1414886268 @default.
- W2559664404 cites W1964728143 @default.
- W2559664404 cites W1965539044 @default.
- W2559664404 cites W1966597723 @default.
- W2559664404 cites W1969205788 @default.
- W2559664404 cites W1970034438 @default.
- W2559664404 cites W1972201752 @default.
- W2559664404 cites W1974316366 @default.
- W2559664404 cites W1975088956 @default.
- W2559664404 cites W1976041621 @default.
- W2559664404 cites W1979507175 @default.
- W2559664404 cites W1983277479 @default.
- W2559664404 cites W1988985710 @default.
- W2559664404 cites W1989230986 @default.
- W2559664404 cites W1990528409 @default.
- W2559664404 cites W1997362118 @default.
- W2559664404 cites W1999578039 @default.
- W2559664404 cites W2002279353 @default.
- W2559664404 cites W2002720916 @default.
- W2559664404 cites W2006194805 @default.
- W2559664404 cites W2006920978 @default.
- W2559664404 cites W2009615462 @default.
- W2559664404 cites W2011260653 @default.
- W2559664404 cites W2019104037 @default.
- W2559664404 cites W2025215537 @default.
- W2559664404 cites W2025628768 @default.
- W2559664404 cites W2027286408 @default.
- W2559664404 cites W2029773805 @default.
- W2559664404 cites W2029871153 @default.
- W2559664404 cites W2037424018 @default.
- W2559664404 cites W2037585162 @default.
- W2559664404 cites W2039181066 @default.
- W2559664404 cites W2040648721 @default.
- W2559664404 cites W2042669918 @default.
- W2559664404 cites W2045735098 @default.
- W2559664404 cites W2049337998 @default.
- W2559664404 cites W2050110132 @default.
- W2559664404 cites W2057255825 @default.
- W2559664404 cites W2057294100 @default.
- W2559664404 cites W2059068537 @default.
- W2559664404 cites W2065013614 @default.
- W2559664404 cites W2066486774 @default.
- W2559664404 cites W2067556994 @default.
- W2559664404 cites W2067608832 @default.
- W2559664404 cites W2072206218 @default.
- W2559664404 cites W2074584736 @default.
- W2559664404 cites W2075337839 @default.
- W2559664404 cites W2076938960 @default.
- W2559664404 cites W2078021081 @default.
- W2559664404 cites W2083710155 @default.
- W2559664404 cites W2087668614 @default.
- W2559664404 cites W2088977947 @default.
- W2559664404 cites W2089716915 @default.
- W2559664404 cites W2090823741 @default.
- W2559664404 cites W2091705186 @default.
- W2559664404 cites W2094471013 @default.
- W2559664404 cites W2094904022 @default.
- W2559664404 cites W2097616315 @default.
- W2559664404 cites W2103827181 @default.
- W2559664404 cites W2110806666 @default.
- W2559664404 cites W2113807798 @default.
- W2559664404 cites W2116756895 @default.
- W2559664404 cites W2117630026 @default.
- W2559664404 cites W2118473182 @default.
- W2559664404 cites W2133897272 @default.
- W2559664404 cites W2138968683 @default.
- W2559664404 cites W2141516981 @default.
- W2559664404 cites W2142239996 @default.
- W2559664404 cites W2150047480 @default.
- W2559664404 cites W2150146274 @default.
- W2559664404 cites W2155825917 @default.
- W2559664404 cites W2157474898 @default.
- W2559664404 cites W2157963288 @default.
- W2559664404 cites W2160626915 @default.
- W2559664404 cites W2169410023 @default.
- W2559664404 cites W2169532237 @default.
- W2559664404 cites W2170546561 @default.
- W2559664404 cites W2190141802 @default.
- W2559664404 cites W2216693079 @default.
- W2559664404 cites W2264732111 @default.
- W2559664404 cites W2313409455 @default.
- W2559664404 cites W2314073965 @default.
- W2559664404 cites W2316142734 @default.
- W2559664404 cites W2322646548 @default.
- W2559664404 cites W2327392120 @default.
- W2559664404 cites W2328743335 @default.
- W2559664404 cites W2406079808 @default.
- W2559664404 cites W2411310478 @default.