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• W2559715481 abstract "Abstract The last 30 years have witnessed tremendous advances in our understanding of the cancer genetic susceptibility syndromes, including those that predispose to hematopoietic malignancies. The identification and characterization of families affected by these syndromes is enhancing our knowledge of the oncologic and nononcologic manifestations associated with predisposing germ line mutations and providing insights into the underlying disease mechanisms. Here, we provide an overview of the cancer genetic susceptibility syndromes, focusing on aspects relevant to the evaluation of patients with leukemia and lymphoma. Guidance is provided to facilitate recognition of these syndromes by hematologists/oncologists, including descriptions of the family history features, tumor genotype, and physical or developmental findings that should raise concern for an underlying cancer genetic syndrome. The clinical implications and management challenges associated with cancer susceptibility syndromes are also discussed." @default.
• W2559715481 created "2016-12-08" @default.
• W2559715481 creator A5025442855 @default.
• W2559715481 creator A5053695390 @default.
• W2559715481 date "2016-12-02" @default.
• W2559715481 modified "2023-09-25" @default.
• W2559715481 title "Introduction to cancer genetic susceptibility syndromes" @default.
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• W2559715481 doi "https://doi.org/10.1182/asheducation-2016.1.293" @default.
• W2559715481 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6142512" @default.
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