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- W2559766507 abstract "Abstract A series of N,N′-dibisphosphonate ethylenediamine derivatives (L1–L6) and their corresponding dichloroplatinum(II) complexes (1–6) have been prepared and characterized by elemental analysis, 1H NMR, 13C NMR, 31P NMR, and HRMS spectra. The in vitro antitumor of compounds L1–L6 and 1–6 was tested by WST-8 assay with Cell Counting Kit-8, indicating that platinum-based complexes 1–6 showed higher cytotoxic efficacy than platinum-free compounds L1–L6 against SKOV3 and MG-63, especially complex 2 (R = CH3, n = 2) with comparable cytotoxicity to cisplatin after 72 h incubation. And complexes 1–6 were highly selective in cytotoxicity against MG-63 tumor cells than hFOB 1.19 normal cells. The in vitro hydroxyapatite binding test revealed that complexes 1 and 2 showed higher affinity (K′ = 4.2 and 3.5, respectively) for bone hydroxyapatite than cisplatin (K′" @default.
- W2559766507 created "2016-12-16" @default.
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- W2559766507 date "2017-03-01" @default.
- W2559766507 modified "2023-09-24" @default.
- W2559766507 title "Synthesis and cytotoxicity of N,N′-dibisphosphonate ethylenediamine derivatives and platinum(II) complexes with high binding property to hydroxyapatite" @default.
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- W2559766507 doi "https://doi.org/10.1016/j.ica.2016.12.006" @default.
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