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- W2559786446 abstract "Significance Neuromyelitis optica (NMO) is a CNS autoimmune demyelinating disease involving aquaporin-4 (AQP4)-specific IgG1, a T-cell–dependent antibody subclass. The role of T cells in NMO is unclear. We evaluated AQP4-specific T cells in WT and AQP4 −/− mice. AQP4 epitopes identified in WT mice were not pathogenic. AQP4 peptide (p) 135–153 and p201–220 elicited robust T-cell responses in AQP4 −/− but not WT, mice. T-cell receptor repertoire utilization for these determinants in AQP4 −/− mice was unique. Donor AQP4 −/− p135–153- or p201–220-specific Th17 cells entered the CNS of recipient WT mice and induced CNS autoimmunity. Our findings indicate pathogenic AQP4-specific T cells are normally restrained by central tolerance, which could be relevant to understanding the origin of pathogenic T cells in NMO." @default.
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- W2559786446 date "2016-12-08" @default.
- W2559786446 modified "2023-10-17" @default.
- W2559786446 title "Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4" @default.
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- W2559786446 doi "https://doi.org/10.1073/pnas.1617859114" @default.
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