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• W2559787462 abstract "Interstitial cells of Cajal (ICCs) function as pacemaker cells in the gastrointestinal (GI) tract and therefore, serve an important role in regulating GI motility. The effects of a species of plum (Prunus mume Siebold & Zucc.) on cultured ICC cluster‑induced pacemaker potentials in the mouse small intestine were investigated, and the effects of a methanolic extract of Prunus mume (m‑PM) on ICC pacemaker activities were examined using the whole‑cell patch‑clamp technique. ICC pacemaker membrane potentials were depolarized by m‑PM in a concentration dependent manner in current clamp mode. 4‑Diphenylacetoxy‑N‑methyl‑piperidine methiodide, which is a muscarinic 3 (M3) receptor antagonist, was able to block m‑PM‑induced pacemaker potential increases, whereas methoctramine, which is a muscarinic 2 (M2) receptor antagonist, was not. When 1 mM guanosine diphosphate β‑5 was present in the pipette solution, m‑PM induced slight pacemaker depolarization. Following pretreatment in bath solution of Ca2+‑free solution or a Ca2+‑ATPase inhibitor in endoplasmic reticulum, the pacemaker currents were inhibited. Furthermore, pretreatment with PD98059, SB203580 or SP600125, which is a c‑jun NH2‑terminal kinase inhibitor, blocked m‑PM‑induced ICC potential depolarization. Furthermore, m‑PM inhibited transient receptor potential melastatin (TRPM) 7 channels, but did not affect Ca2+‑activated Cl‑ channels. These results suggest that m‑PM is able to modulate pacemaker potentials through the muscarinic M3 receptor, via G‑protein and external and internal Ca2+, in a mitogen‑activated protein kinase and TRPM7‑dependent manner. Therefore, m‑PM may provide a basis for the development of a novel gastroprokinetic agent." @default.
• W2559787462 created "2016-12-16" @default.
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• W2559787462 date "2016-12-07" @default.
• W2559787462 modified "2023-10-01" @default.
• W2559787462 title "Effects of Prunus mume Siebold & Zucc. in the pacemaking activity of interstitial cells of Cajal in murine small intestine" @default.
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• W2559787462 doi "https://doi.org/10.3892/etm.2016.3963" @default.
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