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- W2559794913 startingPage "278" @default.
- W2559794913 abstract "Oxidative stress is associated with a growing number of diseases that span from cancer to neurodegeneration. Most oxidatively induced DNA base lesions are repaired by the base excision repair (BER) pathway which involves the action of various DNA glycosylases. There are numerous genome wide studies attempting to associate single-nucleotide polymorphisms (SNPs) with predispositions to various types of disease; often, these common variants do not have significant alterations in their biochemical function and do not exhibit a convincing phenotype. Nevertheless several lines of evidence indicate that SNPs in DNA repair genes may modulate DNA repair capacity and contribute to risk of disease. This overview provides a convincing picture that SNPs of DNA glycosylases that remove oxidatively generated DNA lesions are susceptibility factors for a wide disease spectrum that includes besides cancer (particularly lung, breast and gastrointestinal tract), cochlear/ocular disorders, myocardial infarction and neurodegenerative disorders which can be all grouped under the umbrella of oxidative stress-related pathologies." @default.
- W2559794913 created "2016-12-16" @default.
- W2559794913 creator A5031888140 @default.
- W2559794913 creator A5032135162 @default.
- W2559794913 creator A5043613075 @default.
- W2559794913 creator A5045380690 @default.
- W2559794913 creator A5059013256 @default.
- W2559794913 creator A5080694325 @default.
- W2559794913 creator A5091681118 @default.
- W2559794913 date "2017-06-01" @default.
- W2559794913 modified "2023-10-18" @default.
- W2559794913 title "Single nucleotide polymorphisms in DNA glycosylases: From function to disease" @default.
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