FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2559853385> ?p ?o ?g. }

• W2559853385 endingPage "173" @default.
• W2559853385 startingPage "162" @default.
• W2559853385 abstract "Summary Introduction Mutations in leucine‐rich repeat kinase 2 ( LRRK 2) are the most prevalent cause of familial and sporadic Parkinson's disease ( PD ). Because most pathogenic LRRK 2 mutations result in enhanced kinase activity, it suggests that LRRK 2 inhibitors may serve as a potential treatment for PD . To evaluate whether LRRK 2 inhibitors are effective therapies for PD , it is crucial to know whether LRRK 2 inhibitors will affect dopaminergic ( DA ergic) neurotransmission. However, to date, there is no study to investigate the impact of LRRK 2 inhibitors on DA ergic neurotransmission. Aims To address this gap in knowledge, we examined the effects of three types of LRRK 2 inhibitors ( LRRK 2‐ IN ‐1, GSK 2578215A, and GNE ‐7915) on dopamine ( DA ) release in the dorsal striatum using fast‐scan cyclic voltammetry and DA neuron firing in the substantia nigra pars compacta ( SN pc) using patch clamp in mouse brain slices. Results We found that LRRK 2‐ IN ‐1 at a concentration higher than 1 μ M causes off‐target effects and decreases DA release, whereas GSK 2578215A and GNE ‐7915 do not. All three inhibitors at 1 μ M have no effect on DA release and DA neuron firing rate. We have further assessed the effects of the inhibitors in two preclinical LRRK 2 mouse models (i.e., BAC transgenic hG 2019S and hR 1441G) and demonstrated that GNE ‐7915 enhances DA release and synaptic vesicle mobilization/recycling. Conclusion GNE ‐7915 can be validated for further therapeutic development for PD ." @default.
• W2559853385 created "2016-12-16" @default.
• W2559853385 creator A5018449221 @default.
• W2559853385 creator A5021212748 @default.
• W2559853385 creator A5021959959 @default.
• W2559853385 creator A5040009629 @default.
• W2559853385 creator A5047091944 @default.
• W2559853385 creator A5066566467 @default.
• W2559853385 date "2016-12-09" @default.
• W2559853385 modified "2023-10-01" @default.
• W2559853385 title "Effects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic Neurotransmission" @default.
• W2559853385 cites W1831076810 @default.
• W2559853385 cites W1906859819 @default.
• W2559853385 cites W1967900265 @default.
• W2559853385 cites W1972097907 @default.
• W2559853385 cites W1977353877 @default.
• W2559853385 cites W1977416735 @default.
• W2559853385 cites W1981561631 @default.
• W2559853385 cites W1987160330 @default.
• W2559853385 cites W1990045885 @default.
• W2559853385 cites W1991732882 @default.
• W2559853385 cites W1992365739 @default.
• W2559853385 cites W2017162768 @default.
• W2559853385 cites W2019238415 @default.
• W2559853385 cites W2025416265 @default.
• W2559853385 cites W2028171714 @default.
• W2559853385 cites W2035289099 @default.
• W2559853385 cites W2046398127 @default.
• W2559853385 cites W2059453317 @default.
• W2559853385 cites W2059514738 @default.
• W2559853385 cites W2063127941 @default.
• W2559853385 cites W2074858155 @default.
• W2559853385 cites W2080967954 @default.
• W2559853385 cites W2097963493 @default.
• W2559853385 cites W2100300726 @default.
• W2559853385 cites W2100894616 @default.
• W2559853385 cites W2110157421 @default.
• W2559853385 cites W2110742691 @default.
• W2559853385 cites W2112286366 @default.
• W2559853385 cites W2116037433 @default.
• W2559853385 cites W2117227053 @default.
• W2559853385 cites W2117667168 @default.
• W2559853385 cites W2120968628 @default.
• W2559853385 cites W2124681346 @default.
• W2559853385 cites W2126537366 @default.
• W2559853385 cites W2130444809 @default.
• W2559853385 cites W2133207125 @default.
• W2559853385 cites W2154915523 @default.
• W2559853385 cites W2171281715 @default.
• W2559853385 cites W2171843685 @default.
• W2559853385 cites W2205544783 @default.
• W2559853385 cites W2234759711 @default.
• W2559853385 cites W2330702681 @default.
• W2559853385 cites W2332237809 @default.
• W2559853385 cites W2395584501 @default.
• W2559853385 cites W4210952882 @default.
• W2559853385 doi "https://doi.org/10.1111/cns.12660" @default.
• W2559853385 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5248597" @default.
• W2559853385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27943591" @default.
• W2559853385 hasPublicationYear "2016" @default.
• W2559853385 type Work @default.
• W2559853385 sameAs 2559853385 @default.
• W2559853385 citedByCount "23" @default.
• W2559853385 countsByYear W25598533852017 @default.
• W2559853385 countsByYear W25598533852018 @default.
• W2559853385 countsByYear W25598533852019 @default.
• W2559853385 countsByYear W25598533852020 @default.
• W2559853385 countsByYear W25598533852021 @default.
• W2559853385 countsByYear W25598533852022 @default.
• W2559853385 countsByYear W25598533852023 @default.
• W2559853385 crossrefType "journal-article" @default.
• W2559853385 hasAuthorship W2559853385A5018449221 @default.
• W2559853385 hasAuthorship W2559853385A5021212748 @default.
• W2559853385 hasAuthorship W2559853385A5021959959 @default.
• W2559853385 hasAuthorship W2559853385A5040009629 @default.
• W2559853385 hasAuthorship W2559853385A5047091944 @default.
• W2559853385 hasAuthorship W2559853385A5066566467 @default.
• W2559853385 hasBestOaLocation W25598533851 @default.
• W2559853385 hasConcept C126322002 @default.
• W2559853385 hasConcept C137183658 @default.
• W2559853385 hasConcept C169760540 @default.
• W2559853385 hasConcept C170493617 @default.
• W2559853385 hasConcept C185592680 @default.
• W2559853385 hasConcept C200170125 @default.
• W2559853385 hasConcept C2776773494 @default.
• W2559853385 hasConcept C2779134260 @default.
• W2559853385 hasConcept C2779734285 @default.
• W2559853385 hasConcept C2780062018 @default.
• W2559853385 hasConcept C2780427247 @default.
• W2559853385 hasConcept C2780938664 @default.
• W2559853385 hasConcept C513476851 @default.
• W2559853385 hasConcept C55493867 @default.
• W2559853385 hasConcept C71924100 @default.
• W2559853385 hasConcept C86803240 @default.
• W2559853385 hasConcept C98274493 @default.
• W2559853385 hasConceptScore W2559853385C126322002 @default.
• W2559853385 hasConceptScore W2559853385C137183658 @default.
• W2559853385 hasConceptScore W2559853385C169760540 @default.

• next