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- W2559861620 abstract "In this paper we provide an overview of the cellular changes that accompany progressive glomeruIosclerosis and tubulointerstitial fibrosis. Emphasis is placed on the role of platelet-derived growth factor (PDGF) in the proliferation of the mesangial cell and interstitial fibroblast. PDGF also stimulates the synthesis and expression of a protein called secreted protein acidic and rich in cysteine (SPARC) and of thrombospondin 1 (TSP1). TSP1 may have an important role in the conversion of transforming growth factor (TGF)-,B from its latent to active form. In turn, TGF-fl appears to have a major role in mediating the extracellular matrix deposition that occurs with progressive glomerular and interstitial scarring. Clin Exp Nephrol 1998;2:307-312" @default.
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- W2559861620 date "1998-01-01" @default.
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- W2559861620 title "Mechanisms of Progressive Glomeruloscleros is and Tubulointerstiti al Fibrosis" @default.
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