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- W2559903204 abstract "Allogeneic hematopoietic stem cell transplan- tation (allo-HSCT) is regarded as a curative option for aggressive adult T cell leukemia-lymphoma (ATL). How- ever, the efficacy and safety of allo-HSCT for ATL with central nervous system (CNS) involvement, which is highly resistant to chemotherapy, remain controversial. We ana- lyzed 10 ATL patients with CNS involvement who received allo-HSCT at three institutions in Nagasaki prefecture between 2000 and 2007. The 3-year overall survival rate was 40%, and the median observation time of the four surviving patients was 1532 days (range 945-2212 days). Two of four surviving patients received highly intensive local treatment for the CNS; one with 26 intrathecal injections of antineo- plastic agents, and the other with whole cerebrospinal irra- diation before transplantation. However, the other two patients received conventional or reduced-intensity condi- tioning with standard intrathecal chemotherapy. Three of the four surviving patients experienced chronic GVHD, and two of three patients with grade 3 or 4 acute GVHD were free from CNS relapse. From these data, it seems that both intensive local treatment for CNS disease and systemic GVHD contributed to the long-term control of CNS involvement. Although our data suggest that allo-HSCT is a therapeutic option for ATL with CNS disease, high trans- plant-related mortality (six cases) indicates the need for further studies to develop more effective procedures for CNS disease, and to reduce transplant-related morbidity." @default.
- W2559903204 created "2016-12-16" @default.
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- W2559903204 date "2011-01-01" @default.
- W2559903204 modified "2023-09-27" @default.
- W2559903204 title "Allogeneic hematopoietic stem cell transplantation for ATL with central nervous system involvement: The Nagasaki Transplant Group experience" @default.
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