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- W2559912875 abstract "microRNAs (miRNAs) are emerging as novel biological targets for medicinal chemists to develop chemical tools for intracellular regulation. In this context, the discovery of small-molecule drugs targeting specific miRNAs and modulating their production or function represents a very promising approach that could be further developed for targeted therapy in miRNA-related pathologies. Here, we describe the design of multimodal small molecules as RNA ligands targeting DICER-mediated miRNA maturation. The synthesis and the biochemical evaluation as ligands of stem-loop-structured precursor microRNAs (pre-miRNAs) are reported." @default.
- W2559912875 created "2016-12-16" @default.
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- W2559912875 date "2016-12-07" @default.
- W2559912875 modified "2023-10-11" @default.
- W2559912875 title "Design of Multimodal Small Molecules Targeting miRNAs Biogenesis: Synthesis and In Vitro Evaluation" @default.
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- W2559912875 doi "https://doi.org/10.1007/978-1-4939-6563-2_10" @default.
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